ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2422

Anti-P. Gingivalis antibody Is Correlated With Severity Of Periodontitis But Not With Rheumatoid Arthritis Disease Activity In RA

Joo Youn Lee1, In Ah Choi2, Jin-Hee Kim3, Kyung-Hwa Kim4, Hye Jin Oh5, Myeong Jae Yoon6, Eun Young Lee2, Eun Bong Lee2, Yong-Moo Lee3 and Young Wook Song1,2, 1Department of Molecular Medicine and Biopharmaceutical Sciences, Seoul National University, Seoul, South Korea, 2Division of Rheumatology, Department of Internal Medicine, Seoul National University, Seoul, South Korea, 3Department of Periodontology, School of Dentistry, Seoul National University, Seoul, South Korea, 4Department of Periodontology and Dental Research Institute, School of Dentistry, Seoul National University, Seoul, South Korea, 5Seoul National University, Seoul, South Korea, 6Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea

Meeting: 2013 ACR/ARHP Annual Meeting

Keywords:

Session Information

Title: Rheumatoid Arthritis: Human Etiology and Pathogenesis II

Session Type: Abstract Submissions (ACR)

Background/Purpose: Periodontitis (PD) has been suggested to be one of risk factors for rheumatoid arthritis (RA). Porphyromonas gingivalis (P. ginvivalis, Pg) is a gram-negative anaerobic bacterium that is recognized as a major pathogenic organism in periodontitis (PD). Anti-enolase 1 (ENO1) antibody is one of the autoantibodies in RA. / This study examined the relationship between serum levels of anti-Pg and anti-ENO1 antibodies and PD severity and RA disease activity in patients with RA.

Methods: 248 Patients with RA and 85 age-, sex- matched non-RA controls were enrolled in this study. After rheumatologic and periodontal examination, serum levels of anti-Pg antibodies and anti-ENO1 antibodies were measured by enzyme-linked immunosorbent assay (ELISA).

Results: Patients with RA showed significantly higher levels of anti-Pg antibodies and, anti-ENO1 antibodies than controls (P= 0.0082, P< 0.0001). Anti-Pg antibodies were strongly correlated with anti-ENO1 antibodies in RA patients (p<0.0001). In active RA, there were significant correlations between anti-Pg antibodies with probing pocket depth (PPD), bleeding on probing (BOP) and clinical attachment level (CAL) (P= 0.0015, P=0.006, P=0.0004). However, there were no correlations of anti-Pg antibodies and periodontal parameters in controls and inactive RA. Anti-ENO1 titer did not correlate with periodontal parameters except bleeding on probing (BOP) in RA. Anti-Pg antibodies were not correlated with RA disease activity except ESR (p= 0.0175). However anti-ENO1 antibodies were significantly correlated with ESR, DAS28-ESR, anti-CCP titer (P= 0.0008, P= 0.0092, P= 0.0129).

Conclusion:  Anti-Pg antibodies and anti-ENO1 antibodies were elevated in RA patients than controls. Anti- Pg antibodies were correlated with severity of PD and anti-ENO1 antibodies were correlated with RA disease activity in RA patients.

Disclosure:

J. Y. Lee,
None;

I. A. Choi,
None;

J. H. Kim,
None;

K. H. Kim,
None;

H. J. Oh,
None;

M. J. Yoon,
None;

E. Y. Lee,
None;

E. B. Lee,
None;

Y. M. Lee,
None;

Y. W. Song,
None.

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