ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2333

High Serum Uric Acid Protects Against Osteoporosis in Postmenopausal Women: Data from the Korean National Health and Nutrition Examination Survey

Eun-Jung Park1, In Young Kim2, Jinseok Kim3, Chan Hong Jeon4, Joong Kyong Ahn5, Hoon-Suk Cha2, Eun-Mi Koh2, Hyungjin Kim2 and Jaejoon Lee6, 1Division of Rheumatology, Department of Medicine, National Medical Center, Seoul, Korea, Republic of (South), 2Division of Rheumatology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South), 3Department of Medicine, Jeju National University Hospital, University of Jeju School of Medicine, Jeju, Korea, Republic of (South), 4Division of Rheumatology, Department of Medicine, Soonchunhyang University College of Medicine, Bucheon, Korea, Republic of (South), 5Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South), 6Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of (South)

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords:

Session Information

Date: Tuesday, October 23, 2018

Title: Osteoporosis and Metabolic Bone Disease – Basic and Clinical Science Poster

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Osteoporosis is one of the most common morbidities in postmenopausal women. Although serum uric acid (SUA) accounts for about 50% of extracellular antioxidant activity, the role of hyperuricemia in osteoporosis, a condition characterized by high oxidative stress level, has not been investigated in a Nation-wide scale. The aim of this study is to evaluate an association between SUA and incidence of osteoporosis in postmenopausal women.

Methods: Data of postmenopausal women from the 2016 Korean National Health and Nutrition Examination Survey were included and retrospectively analyzed. Weighted prevalence and logistic regression analysis were used to determine the incidence of osteoporosis and the effect of SUA on osteoporosis in postmenopausal women.

Results: One-thousand three-hundred eighty-two (weighted n = 7,064,137) of postmenopausal women were observed. Of these, 401 (29.0 %, weighted n = 1,880,586) women developed osteoporosis. Mean age of participants was 63.2 years and mean of SUA was 4.4 mg/dL. The effect of SUA on osteoporosis in postmepausal women was not statistically significant according to univariable logistic regression (OR 0.977, 95 % CI 0.855-1.116, p = 0.729). However, SUA was negatively associated with incidence of osteoporosis in postmenopausal women with statistical significance after adjusting for age, obesity, amount of drink, smoking, intake of calcium, rheumatoid arthritis, thyroid diseases, and loss of activity (OR 0.867, 95 % CI 0.752-0.999, p = 0.048).

Conclusion: Our data demonstrated that high SUA is associated with lower incidence of osteoporosis in postmenopausal women. This result suggests a protective role of SUA in metabolic bone diseases.

Disclosure: E. J. Park, None; I. Y. Kim, None; J. Kim, None; C. H. Jeon, None; J. K. Ahn, None; H. S. Cha, None; E. M. Koh, None; H. Kim, None; J. Lee, None.

To cite this abstract in AMA style:

Park EJ, Kim IY, Kim J, Jeon CH, Ahn JK, Cha HS, Koh EM, Kim H, Lee J. High Serum Uric Acid Protects Against Osteoporosis in Postmenopausal Women: Data from the Korean National Health and Nutrition Examination Survey [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/high-serum-uric-acid-protects-against-osteoporosis-in-postmenopausal-women-data-from-the-korean-national-health-and-nutrition-examination-survey/. Accessed .

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