ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 707

Subclinical Parameters of Arterial Stiffness and Arteriosclerosis Correlate with QRISK3 in Systemic Lupus Erythematosus

Monica Vazquez-Del Mercado1,2, Felipe Perez-Vazquez3, Eduardo Gomez-Bañuelos1, Efrain Chavarria-Avila3, Arcelia Llamas-Garcia4, Karla I. Arrona-Rios4, Gustavo I Diaz-Rubio3, Sergio Duran-Barragan4, Rosa E Navarro-Hernandez3, Bethel Jordan-Estrada3, Natalia Prado-Bachega5, Miguel A. A. Gonzalez-Beltran3, Carlos G Ramos-Becerra6, Fernando Grover-Paez6, David Cardona-Muller7 and Ernesto German Cardona-Muñoz7, 1Servicio de Reumatología, 004086 PNPC CONACyT, Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Guadalajara, Mexico, 2Centro Universitario de Ciencias de la Salud, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Universidad de Guadalajara Centro Universitario de Ciencias de la Salud, Guadalajara, Mexico, 3Centro Universitario de Ciencias de la Salud, Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Universidad de Guadalajara, Guadalajara, Mexico, 4Servicio en Reumatología, 004086 PNPC CONACyT, Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Guadalajara, Mexico, 5Anesthesiology, Hospital Civil de Guadalajara Dr. Juan I. Menchaca, Guadalajara, Mexico, 6Centro Universitario de Ciencias de la Salud, INTEC, Universidad de Guadalajara, Guadalajara, Mexico, 7Departamento de Fisiología, Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Jalisco, Mexico

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: ,

Session Information

Date: Sunday, October 21, 2018

Title: Systemic Lupus Erythematosus – Clinical Poster I: Clinical Manifestations and Comorbidity

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose:

It is well known that cardiovascular diseases (CVD) are a major contributor of death in systemic lupus erythematosus (SLE) as well in other rheumatic illness. In the last decades, there has been a growing development of different methodologies with the purpose of early detection of CVD. The aim of this study is to correlate the usefulness of subclinical parameters of vascular aging and QRISK¨ 3-2017 score for early detection of CVD in SLE.

Methods:

Clinical assessment including systemic lupus erythematosus disease activity index (SLEDAI) and systemic lupus international collaborating clinics / american college of rheumatology damage index (SLICC/ACR DI), laboratory measurements, carotid ultrasound examination, carotid intima media thickness (cIMT) measurement, carotid distention and diameter analysis, arterial stiffness measurement measured by tonometry and QRISK¨ 3-2017 were done. All results were analyzed by SPSS 24 software.

Results:

We observed correlation between QRISK3 and mean cIMT (rs = 0.651, P < 0.001), PWV (rs = 0.627, P < 0.001), cfPWV (rs = 0.651, P < 0.001) and distensibility (rs = 0.555, P = 0.001). Consistent with above, SLE patients in middle and high risk QRISK¨ 3-2017 showed increased arterial stiffness versus low risk group.

Conclusion:

We encourage to the rheumatology community to assess cardiovascular risk in SLE patients with QRISK¨ 3-2017 risk calculator as an alternative method at the outpatient clinic along a complete cardiovascular evaluation when appropriate.

Disclosure: M. Vazquez-Del Mercado, None; F. Perez-Vazquez, None; E. Gomez-Bañuelos, None; E. Chavarria-Avila, None; A. Llamas-Garcia, None; K. I. Arrona-Rios, None; G. I. Diaz-Rubio, None; S. Duran-Barragan, None; R. E. Navarro-Hernandez, None; B. Jordan-Estrada, None; N. Prado-Bachega, None; M. A. A. Gonzalez-Beltran, None; C. G. Ramos-Becerra, None; F. Grover-Paez, None; D. Cardona-Muller, None; E. G. Cardona-Muñoz, None.

To cite this abstract in AMA style:

Vazquez-Del Mercado M, Perez-Vazquez F, Gomez-Bañuelos E, Chavarria-Avila E, Llamas-Garcia A, Arrona-Rios KI, Diaz-Rubio GI, Duran-Barragan S, Navarro-Hernandez RE, Jordan-Estrada B, Prado-Bachega N, Gonzalez-Beltran MAA, Ramos-Becerra CG, Grover-Paez F, Cardona-Muller D, Cardona-Muñoz EG. Subclinical Parameters of Arterial Stiffness and Arteriosclerosis Correlate with QRISK3 in Systemic Lupus Erythematosus [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/subclinical-parameters-of-arterial-stiffness-and-arteriosclerosis-correlate-with-qrisk3-in-systemic-lupus-erythematosus/. Accessed .

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