Association of Rheumatoid Arthritis and Other Autoinmune Diseases

Eliana Rebeca Serrano¹, Julia Sosa², María Paula Kohan², María Julia Santa Cruz¹, María Alejandra Medina¹, Diana Silvia Klajn³, Silvia Beatriz Papasidero⁴, José Ángel Caracciolo¹, Mariana Benegas⁵, Etel Saturansky⁶, Rosana Quintana⁷, Bernardo Pons Estel⁷, Dora Pereira⁸, Analía Dellepiane⁹, Rodrigo García Salinas¹⁰, María de los Angeles Correa¹¹, Gustavo Citera¹², Mónica Sacnun¹³, Claudia Hartvig¹⁴, Julia Demarchi¹⁵, Guillermo Bartel¹⁵, Andrea Gómez¹⁵, Karin Kirmayr¹⁶, José Velasco Zamora¹⁷, Yamila Chichotky¹⁸, María Marta Zalazar¹⁹, Oscar Rillo³, Analía Bohr²⁰, Adriana Pérez Dávila²¹, Hugo Najera²², Anastasia Secco²², Rene Jearmany Chuquimia²², Alejandro Martinez Muñoz²³, Emilio Buschiazzo²⁴, Ricardo Vicente Juárez²⁵, Laura Raiti²⁶, Vanesa Cruzat²⁶, Andrea Smichowski²⁷, Gustavo Casado²⁷, David Marcos Zelaya²⁸, Damaris Álvarez²⁸, Eduardo Kerzberg²⁹, Javier Rosa³⁰, Victoria García³¹, Cinthya Retamozo³², Ana Carolina Costi³³, Claudia Pena³⁴ and Hernán Maldonado Ficco³⁵, ¹Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Buenos Aires, Argentina, ²Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Argentina, CABA, Argentina, ³Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, CABA, Argentina, ⁴Rheumatology Section, Hospital General de Agudos Dr. Enrique Tornú, Argentina, Buenos Aires, Argentina, ⁵Rheumatology Section, Sanatorio Dr. Julio Méndez, Buenos Aires, Argentina, ⁶Rheumatology Section, Sanatorio Dr. Julio Méndez, CABA, Argentina, ⁷Rheumatology Section, Sanatorio Parque S.A., Rosario, Argentina, ⁸Rheumatology Section, Hospital Dr. Ricardo Gutiérrez, Argentina, Buenos Aires, Argentina, ⁹Rheumatology Section, CEMEC, Casilda-Santa Fe, Argentina, ¹⁰Rheumatology Section, Hospital Italiano de La Plata, La Plata, Argentina, ¹¹Rheumatology Section, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina, ¹²Rheumatology Section, Instituto de Rehabilitación Psicofísica, CABA, Argentina, ¹³Rheumatology Section, Hospital Provincial de Rosario, Rosario, Argentina, ¹⁴Rheumatology Section, Hospital Provincial de Rosario, Rosario-Santa Fe, Argentina, ¹⁵Rheumatology Section, Hospital Británico de Buenos Aires, CABA, Argentina, ¹⁶Rheumatology Section, Sanatorio San Carlos de Bariloche, Bariloche, Argentina, ¹⁷Rheumatology Section, Reumatologia al Sur, Berazategui- Buenos Aires, Argentina, ¹⁸Rheumatology Section, Reumatologia al sur, Berazategui- Buenos Aires, Argentina, ¹⁹Rheumatology Section, Hospital General de Agudos Dr. Ignacio Pirovano, Buenos Aires, Argentina, ²⁰Rheumatology Section, Hospital de Rehabilitación Manuel Rocca, Buenos Aires, Argentina, ²¹Rheumatology Section, Hospital de Rehabilitación Manuel Rocca, CABA, Argentina, ²²Rheumatology Section, Hospital Bernardino Rivadavia, CABA, Argentina, ²³Rheumatology Unit, Hospital General de Agudos Dr. E. Tornú, San Miguel- Buenos Aires, Argentina, ²⁴Rheumatology Section, Hospital Señor del Milagro, Salta, Argentina, ²⁵Rheumatology Section, Hospital Señor del Milagro de Salta, Salta, Argentina, ²⁶Rheumatology Section, Clínica Bessone, San Miguel- Buenos Aires, Argentina, ²⁷Rheumatology Section, Hospital Militar Central, CABA, Argentina, ²⁸Rheumatology Section, Hospital General de Agudos José María Ramos Mejía, CABA, Argentina, ²⁹Rheumatology Section, Hospital General de Agudos José María Ramos Mejía, Buenos Aires, Argentina, ³⁰Rheumatology Unit, Internal Medicine Service, Hospital Italiano de Buenos Aires, Capital Federal, Argentina, ³¹Rheumatology Section, Hospital Italiano de Buenos Aires, CABA, Argentina, ³²Rheumatology Section, Centro Especializado Diabetes y Reumatologia, Orán- Salta, Argentina, ³³Rheumatology Section, Hospital Interzonal General de Agudos Gral. José de San Martín, La Plata, Buenos Aires, Argentina, ³⁴Rheumatology Section, Hospital San Martín de La Plata, La Plata- Buenos Aires, Argentina, ³⁵Rheumatology Section, Hospital San Antonio de Padua, Río Cuarto- Córdoba, Argentina

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: autoimmune diseases and rheumatoid arthritis (RA)

Session Information

Date: Sunday, October 21, 2018

Title: Rheumatoid Arthritis – Diagnosis, Manifestations, and Outcomes Poster I: Comorbidities

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: The coexistence of different autoimmune diseases (AID) has been well established in the literature. In our knowledge, there is no study assessing specifically the association between RA and other AID. The aim of our study was to determine the frequency of AID in RA patients and to compare this frequency between patients with and without RA or other rheumatologic AID.

Methods: Multicenter, observational, analytical, retrospective study, including consecutive patients with diagnosis of RA (ACR/EULAR 2010 criteria). Patients with initial diagnosis of primary ostearthritis (OA) were used as control group.

Results: A total of 1549 patients from 23 centers were included: 831 RA [84% women, mean age 55.2 (±13.6)] and 718 OA [82% women, mean age 67 (± 11.1)]. Mean age at RA symptoms onset was 45.5 (± 13.4). Most patients (90.5%) were treated with DMARDs and 34.3% with biologic drugs. The frequency of AID in the RA group was 22% (n=183). RA patients showed higher frequency of rheumatologic AID (9.4 vs 3.3%, p< 0.001), and lower frequency of non-rheumatologic AID than OA patients (15.3 vs 20.5%, p= 0.007). The most frequent rheumatologic AID was Sjögren´s Syndrome (SS), with a higher prevalence in RA patients (87.2 vs 29.2%, p<0.001). There was no difference in the frequency of other pathologies. The frequency of rheumatologic AID in RA patients was higher in those with erosive RA (11 vs 6.8%, p=0.048). No association with gender, age, nodular RA or seropositivity was observed. A lower age at RA diagnosis was associated with lower age at thyroid AID (39 vs 48.2, p=0.0001) and SS diagnosis (41.3 vs 57.1, p< 0.0001). Family history of AID was higher in RA patients (24.4 vs 13.4%, p< 0.001). In the control group, family history of AID was associated with higher frequency of non-rheumatologic AID (36.2 vs 20.9%, p= 0.005), mostly thyroid diseases.

Conclusion: The frequency of AID in RA patients was 22%. Rheumatologic AID were more frequent in RA patients, mostly in those with erosive RA, whereas non-rheumatologic AID prevailed in OA patients. Family history of AID, mainly rheumatologic ones, was higher in RA patients.

Disclosure: E. R. Serrano, None; J. Sosa, None; M. P. Kohan, None; M. J. Santa Cruz, None; M. A. Medina, None; D. S. Klajn, None; S. B. Papasidero, None; J. Á. Caracciolo, None; M. Benegas, None; E. Saturansky, None; R. Quintana, None; B. Pons Estel, None; D. Pereira, None; A. Dellepiane, None; R. García Salinas, None; M. D. L. A. Correa, None; G. Citera, Novartis, Pfizer Inc, 2,AbbVie, Bristol-Myers Squibb, Eli Lilly, Genzyme, Novartis, Pfizer Inc, Roche, 5; M. Sacnun, None; C. Hartvig, None; J. Demarchi, None; G. Bartel, None; A. Gómez, None; K. Kirmayr, None; J. Velasco Zamora, None; Y. Chichotky, None; M. M. Zalazar, None; O. Rillo, None; A. Bohr, None; A. Pérez Dávila, None; H. Najera, None; A. Secco, None; R. J. Chuquimia, None; A. Martinez Muñoz, None; E. Buschiazzo, None; R. V. Juárez, None; L. Raiti, None; V. Cruzat, None; A. Smichowski, None; G. Casado, None; D. M. Zelaya, None; D. Álvarez, None; E. Kerzberg, None; J. Rosa, None; V. García, None; C. Retamozo, None; A. C. Costi, None; C. Pena, None; H. Maldonado Ficco, None.

To cite this abstract in AMA style:

Serrano ER, Sosa J, Kohan MP, Santa Cruz MJ, Medina MA, Klajn DS, Papasidero SB, Caracciolo JÁ, Benegas M, Saturansky E, Quintana R, Pons Estel B, Pereira D, Dellepiane A, García Salinas R, Correa MDLA, Citera G, Sacnun M, Hartvig C, Demarchi J, Bartel G, Gómez A, Kirmayr K, Velasco Zamora J, Chichotky Y, Zalazar MM, Rillo O, Bohr A, Pérez Dávila A, Najera H, Secco A, Chuquimia RJ, Martinez Muñoz A, Buschiazzo E, Juárez RV, Raiti L, Cruzat V, Smichowski A, Casado G, Zelaya DM, Álvarez D, Kerzberg E, Rosa J, García V, Retamozo C, Costi AC, Pena C, Maldonado Ficco H. Association of Rheumatoid Arthritis and Other Autoinmune Diseases [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/association-of-rheumatoid-arthritis-and-other-autoinmune-diseases/. Accessed .

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