ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 385

Sexual Dysfunction in Female Patients with Idiopathic Inflammatory Myopathies

Barbora Hermankova1,2, Maja Spiritovic1,2, Hana Smucrova2, Sabina Oreska2,3, Hana Storkanova2,3, Karel Pavelka3,4, Ladislav Šenolt2,3, Herman F Mann2,5, Jiri Vencovsky2,6 and Michal Tomcik2,3, 1Department of Physiotherapy, Faculty of Physical Education and Sports, Charles University, Prague, Czech Republic, Prague, Czech Republic, 2Institute of Rheumatology, Prague, Czech Republic, Prague, Czech Republic, 3Department of Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 4Institute of Rheumatology, Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 5First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic, 6Department Rheumatology, First Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords:

Session Information

Date: Sunday, October 21, 2018

Title: Muscle Biology, Myositis and Myopathies Poster I: Clinical Features and Disease Course

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Idiopathic inflammatory myopathies (IIM) are characterized by inflammation and atrophy of skeletal muscles, pulmonary and articular involvement, which leads to functional impairment, reduced quality of life including sexual life. The aim of this study was to assess sexual functions/quality of life and pelvic floor function in female IIM patients compared to age-/sex-matched healthy controls (HC).

Methods: In total, 22 women with IIM [mean age: 55.1, disease duration: 7.9 years, dermatomyositis (DM, 8)/ polymyositis (PM, 10)/ necrotizing myopathy (IMNM, 3)/ inclusion body myositis (IBM, 1)], who fulfilled the Bohan/Peter 1975 criteria for DM/PM, and 22 healthy controls (mean age: 55.1 years) without rheumatic diseases filled in 12 well-established and validated questionnaires assessing sexual function/quality of life, pelvic floor function, fatigue, physical activity and depression. Data are presented as mean ±SEM.

Results: Compared to HC, patients with IIM had significantly higher prevalence and greater severity of sexual dysfunction (FSFI, BISF-W: in all subscales as well as total scores), dysfunction of pelvic floor (PISQ-12), and worse sexual quality of life (SQoL-F) (table). Worse scores in IIM patients were associated with elevated muscle enzyme levels [lactate dehydrogenase: FSFI (r=-0.524,p=0.0123), BISFW (r=-0.528,p=0.0115)], greater fatigue [FIS: FSFI (r=-0.434,p=0.0438), BISF-W (r=-0.488, p=0.0211), SQoL-F (r=-0.488,p=0.0070), PISQ-12 (r=0.643,p=0.0013)], more severe depression [BDI-II: PISQ-12 (r=0.474,p=0,0258)], deteriorated quality of life [HAQ: PISQ-12 (r=0.476,p=0.0252)], and worse ability to perform physical activities [HAP: FSFI (r=0.437,p=0.0417), BISF-W (r=0.451,p=0.0351), PISQ-12 (r=-0.494,p=0.0195)].

Conclusion:

Women with IIM reported significantly impaired sexual function, sexual quality of life and pelvic floor function than age-matched healthy controls. Worse scores in IIM were associated with disease activity, physical activity, fatigue, depression and quality of life.

Acknowledgements: Supported by AZV-16-33574A, MHCR 023728

Questionnaire: score range

Idiopathic inflammatory myopathies (n=22)

Healthy controls

(n=22)

p-value

FSFI: Female Sexual Function Index: 2(worst)-36(best)

14.2±2.7

23.5±2.5

p=0.0146

BISF-W: Brief Index of Sexual Function for Women: -16(worst)-75(best)

15.5±3.9

28.9±3.8

p=0.0193

PISQ–12: Pelvic Organ Prolapse/Urinary Incontinence Sexual Questionnaire short form: 0(best)-48(worst)

13.8±1.1

8.0±1.0

p=0.0003

PFIQ7: Pelvic Floor Distress Inventory Questionnaire – short form 7:

0(best)-300(worst)

15.8±4.5

5.6±2.3

p=0.1450

SQoL-F: Sexual Quality of Life Questionnaire – Female: 0(worst)-100(best)

54.9±6.0

83.1±3.4

p-0.0006

FSS: Fatigue Severity Scale: 9(best)-63(worst)

46.9±2.8

26.7±2.5

p<0.0001

FIS: Fatigue Impact Scale: 0(best)-160(worst)

60.6±6.9

29.0±4.2

p=0.0003

MAF: Multidimensional Assessment of Fatigue Scale: 1(best)-50(worst)

26.1±2.3

17.8±1.4

p=0.0129

BDI-II: Beck’s Depression Inventory II: 0(best)-63(worst)

14.5±2.2

5.3±1.1

p=0.0003

HAP: Human Activity Profile – adjusted activity score: 0(worst)-94(best)

53.7±4.3

81.1±1.5

p<0.0001

HAQ: Health Assessment Questionnaire: 0(best)-3(worst)

1.0±0.2

0.0±0.0

p<0.0001

Disclosure: B. Hermankova, None; M. Spiritovic, None; H. Smucrova, None; S. Oreska, None; H. Storkanova, None; K. Pavelka, None; L. Šenolt, None; H. F. Mann, None; J. Vencovsky, None; M. Tomcik, None.

To cite this abstract in AMA style:

Hermankova B, Spiritovic M, Smucrova H, Oreska S, Storkanova H, Pavelka K, Šenolt L, Mann HF, Vencovsky J, Tomcik M. Sexual Dysfunction in Female Patients with Idiopathic Inflammatory Myopathies [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/sexual-dysfunction-in-female-patients-with-idiopathic-inflammatory-myopathies/. Accessed .

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