ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 305

Introduction and Value of a Shortened Psamris-7 in Psa-Patients before and after Treatment Escalation to Bdmard Using High Resolution MRI

Philipp Sewerin1, Daniel Benjamin Abrar2, Christine Goertz3, Marco Jung4, Matthias Schneider5, Benedikt Ostendorf1 and Christoph Schleich6, 1Department and Hiller-Research-Unit for Rheumatology, Heinrich-Heine University, Düsseldorf, Germany, 2Department for diagnostic and interventional Radiology, Heinrich-Heine-Universitiy, Duesseldorf, Germany, 3Department and Hiller-Research-Unit for Rheumatology, Heinrich-Heine-Universitiy, Duesseldorf, Germany, 4Department and Hiller-Research-Unit for Rheumatologie, Heinrich-Heine Universitiy, Duesseldorf, Germany, 5Department and Hiller-Research-Unit for Rheumatology, Heinrich-Heine University, Duesseldorf, Germany, 6Department for diagnostic and interventional Radiology, Heinrich-Heine University, Duesseldorf, Germany

Meeting: 2018 ACR/ARHP Annual Meeting

Keywords: ,

Session Information

Date: Sunday, October 21, 2018

Title: Imaging of Rheumatic Diseases Poster I: MRI

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: The aim of the study was to evaluate a simplified version of the OMERACT Psoriasis Arthritis Magnetic Resonance Imaging Score (PsAMRIS) to seven regions of the clinically dominant hand in patients with psoriasis arthritis (PsA) before and after treatment escalation to biological Disease-Modifying Antirheumatic Drugs (bDMARDs) using high resolution, 3 Tesla (T) MRI.

Methods: 18 patients with PsA according to the CASPAR classification criteria (Ø 47 years ± 16) who qualified for bDMARD therapy due to inadequate Methotrexate (MTX) treatment, were prospectively assessed by both baseline investigation and 6 months after therapy escalation including clinical examination (CRP and DAS 28) and 3T MRI of the clinically dominant hand. Scans were analyzed by two independent experts (PS/CS) using the OMERACT PsAMRIS and the simplified PsAMRIS-7 which includes all distal interphalangeal joints (DIP), proximal interphalangeal joint (PIP) and metacarpophalangeal joint (MCP) of the index (PIP and MCP II).

Results: On average, PsAMRIS rating lasts 312 seconds (s; SD= 40.9); PsAMRIS-7 scoring was 116s (SD=20.9), on average. We found no correlation between DAS28 and / or CRP to PsAMRIS (r=-0.044 / r=-0.23) or PsAMRIS-7 (r=-0.094 / r=-0.13). In contrast, there was a strong correlation between OMERACT PsAMRIS and the simplified PsAMRIS-7 at baseline (r=0.871; p=<0.01) and after six months (r=0,907; p=<0.01).

Conclusion: The simplified PsAMRIS-7, using 3T MRI, is a time and resource saving shortened version of the OMERACT PsAMRIS and a reliable tool for detecting morphological changes in PsA. Hence, the shortened PsAMRIS-7 may have the potential to apply in diagnosis and therapy monitoring of PsA patients. Therefor PsAMRIS-7 needs to be investigated in larger clinical studies.

Disclosure: P. Sewerin, None; D. B. Abrar, None; C. Goertz, None; M. Jung, None; M. Schneider, None; B. Ostendorf, None; C. Schleich, None.

To cite this abstract in AMA style:

Sewerin P, Abrar DB, Goertz C, Jung M, Schneider M, Ostendorf B, Schleich C. Introduction and Value of a Shortened Psamris-7 in Psa-Patients before and after Treatment Escalation to Bdmard Using High Resolution MRI [abstract]. Arthritis Rheumatol. 2018; 70 (suppl 9). https://acrabstracts.org/abstract/introduction-and-value-of-a-shortened-psamris-7-in-psa-patients-before-and-after-treatment-escalation-to-bdmard-using-high-resolution-mri/. Accessed .

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