Session Information
Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose:
The natural history of psoriatic arthritis (PsA) is hardly known and the information regarding PsA prospective cohorts is very scarce worldwide. The information obtained from prospective cohorts of rheumatic diseases of recent onset is the only way to unravel the true natural history of these diseases. Our objective was to describe the baseline characteristics of the REAPSER (Recent-Onset PsA Registry of the Spanish Society of Rheumatology) cohort, a prospective cohort that seeks to know the natural history and the impact that the disease generates in Spanish patients with PsA.
Methods:
REAPSER is an observational, multicenter study, with consecutive recruitment, which includes adults of both sexes aged 18 yr or older that meet CASPAR criteria for PsA, and have less than two years of disease evolution (recent-onset PsA). Annual follow-up visits will be carried out for 5 years. Measurements include socio-demographic data, employment status, impact of disease, family history of PsA and other inflammatory diseases, comorbidities, lifestyle, use of health services, clinical status at disease presentation and during follow up, anthropometric data, clinical evaluation, radiographic progression, lab determinations, and treatment of the disease. The study has been approved by the ethical committees of the participating centers.
The statistical analysis is limited to describing percentages for qualitative variables and central measurements with dispersion values for the quantitative ones.
Results:
Two hundred and fifteen consecutive patients were included, mean age 49.8 ± 13.9 years.
|
Parameter |
N: 215 |
|
Men Women Active worker Unemployed Retired / pensioner Job change last year University studies Smoking BMI Weekly alcohol consumption (SDU) Family history of psoriasis Family history of PsA Family history of other arthritis Charlson’s Comorbidity Index Psoriasis at baseline PASI Joint pattern TJC68 SJC66 BASDAI Dactylitis Enthesitis Uveitis Pain VAS Patient´s global disease activity HAQ PsAID Steinbrocker Index (0-168) Cardiovascular events HLA-B27 ESR NSAIDs GC Synthetic DMARDs Biological DMARDS |
67.4% 32.6% 59.5% 12.1% 17.7% 4.7% 20% 30.2% 27.7 ± 5.2 0 SDU (0-4) 41.4% 9.3% 6.5% 0: 46.5%. 1-2: 35.3%. 3-4: 14.4%. >4: 3.8% 88% 1.5 (0.6-4.3) Peripheral: 81.5%. Axial: 5.2%. Mixed: 13.3% 4 (2-8) 2 (1-4) 3.9 (3-4.4) 41.9% 25% 0.5% 5 (3-7) 5 (3-7) 0.5 (0.1-4) 3.8 (1.8-6) 0 (0-4) 5.7% 12.3% 13 (6-25) 75% 28.3% 53.2% 1.5% |
Values are expressed as percentages, means with standard deviation, and medians with IQR (interquartile range). SDU: Standard Drink Units. PsAID: Psoriatic Arthritis Impact of Disease.
Conclusion:
The baseline situation of Spanish patients with recent-onset PsA corresponds to that of a disease with slight cutaneous involvement and predominance of oligoarticular arthritis. Unsurprisingly, structural damage is scarce but not zero. The impact of the disease is still low in these early stages, however 18% of patients have a high Charlson´s comorbidity index (> 3) and almost 5% of patients changed their employment status in the last year due to their PsA.
To cite this abstract in AMA style:
Queiro R, Laiz A, Montilla-Morales CA, Galindez-Agirregoikoa E, Bethencourt JJ, Seoane D. Baseline Data from the Recent-Onset Psoriatic Arthritis Registry of the Spanish Society of Rheumatology [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/baseline-data-from-the-recent-onset-psoriatic-arthritis-registry-of-the-spanish-society-of-rheumatology/. Accessed .« Back to 2017 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/baseline-data-from-the-recent-onset-psoriatic-arthritis-registry-of-the-spanish-society-of-rheumatology/