ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1654

Predictive Factors According to Type of Infection in Systemic Lupus Erythematosus Patients: Data from a Multi-Ethnic, Multi-National, Latin-American Cohort

Victor R. Pimentel-Quiroz1, Manuel Ugarte-Gil1, Guillermo J. Pons-Estel2, Daniel Wojdyla3, Mario Cardiel4, Virginia Pascual-Ramos5, Ignacio Garcia-De La Torre6, Leonor Barile7, Mary Carmen Amigo8, Luis H. Silveira9, Maria Josefina Sauza del Pozo10, Marlene Guibert-Toledano11, Gil A. Reyes12, Antonio Iglesias-Gamarra13, Gloria Vasquez14, José Fernando Molina15, Jose A Gómez-Puerta16, Luis Alonso Gonzalez17, Rosa Chacón-Díaz18, Maria H Esteva Spinetti19, Isaac Abadi19, Eduardo M. Acevedo-Vásquez20, Jose Alfaro-Lozano21, Ines Segami22, Loreto Massardo23, Oscar Neira23, Emilia Sato24, Eloisa Bonfa25, Eduardo Borba26, Graciela S. Alarcón27 and Bernardo Pons-Estel28, 1Peru, GLADEL, Lima, Peru, 2GLADEL, Rosario, Argentina, 3GLADEL consultant, Rosario, Argentina, 4Centro de Investigación Clínica de Morelia SC, Morelia, Mexico, 5Instituto Nacional de Ciencias Médicas y Nutrició, Mexico City, Mexico, 6Immunology & Rheumatology, Centro de Est. de Invest. Bas. y Clin., S.C., Guadalajara, JAL, Mexico, 7GLADEL, Mexico, Mexico, 8Centro Medico ABC, Mexico, Mexico, 9Rheumatology, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City DF, Mexico, 10Servicio de Reumatología, Instituto Mexicano de Seguro Social, Hospital de Especialidades Nº 25, Monterrey, Mexico, 11Centro de Investigaciones Médico Quirúrgicas, Habana, Centro de Investigaciones Médico Quirúrgicas, Habana, La Habana, Cuba, 12GLADEL, Havana, Cuba, 13Clinical Development, Nordic Bioscience, Herlev, Denmark, 14GLADEL, Colombia, Antioquia, Colombia, 15GLADEL, Colombia, Antoquia, Colombia, 16Grupo de Reumatología, Universidad de Antioquia, Medellín, Colombia, 17Medicarte IPS, Medellín, Colombia, 18Servicio de Reumatología, Hospital Universitario de Caracas, Centro Nacional de Enfermedades Reumáticas, Caracas, Venezuela, 19GLADEL, Caracas, Venezuela (Bolivarian Republic of), 20Hospital Nacional Guillermo Almenara Irigoyen, Lima, Peru, 21Rheumatology, Hospital Guillermo Almenara Irigoyen. EsSalud, Lima, Peru, 22GLADEL, Peru, Lima, Peru, 23GLADEL, Santiago, Chile, 24Rheumatology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil, 25Rheumatology Divison, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 26Faculdade de Medicina, Hospital das Clínicas. Universidade de São Paulo, São Paulo, Brazil, 27University of Alabama at Birmingham, Birmingham, AL, 28GLADEL, Rosario, Santa Fe, Argentina

Meeting: 2017 ACR/ARHP Annual Meeting

Date of first publication: September 18, 2017

Keywords:

Session Information

Date: Monday, November 6, 2017

Title: Systemic Lupus Erythematosus – Clinical Aspects and Treatment Poster II: Damage and Comorbidities

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: While infections are a one of the main causes of mortality in systemic lupus erythematosus (SLE), the type of infections and the factors predisposing to them have not been properly evaluated. The aim of the present study was to identify predictive factors accounting for the different types of infections in SLE patients.

Methods: A multi-ethnic, multi-national cohort from nine countries was utilized for these analyses. The following type of infections were considered: skin, lung, urinary tract, digestive tract and gynecological. Cox regression models were used to evaluate the predictors of new infections (global and per organs involved) using a backward elimination procedure. Potential predictors were demographic factors, clinical manifestations, SLEDAI, SDI and treatment at baseline.

Results: Predictive factors of skin infections were dose of prednisone between 15 and 60mg/d (HR: 1.73; CI: 1.16-2.57) and ≥60mg/d (HR: 1.63; CI: 1.01-1.91), lymphopenia (HR: 1.38; CI: 1.01-1.91), shorter disease duration at baseline (HR: 0.94; CI: 0.91-0.97), and previous infections (HR: 1.77; CI: 1.18-2.65). Predictive factors of lower airway infections were previous infections (HR: 2.39; CI: 1.38-4.13), lung involvement (HR: 2.81; CI: 1.38-5.71), and shorter disease duration at baseline (HR: 0.94; CI: 0.90-0.98). Predictive factors of urinary tract infections were higher damage at baseline (HR: 1.17; CI: 1.02-1.35), older age at diagnosis (HR: 1.02; CI: 1.01-1.03), shorter disease duration at baseline (HR: 0.93; CI: 0.89-0.96), female gender (HR: 3.03; CI: 1.11-8.23), and Mestizo ethnicity (HR: 1.98; CI: 1.29-3.04). Predictive factors of digestive tract infections were higher disease activity at baseline (HR: 1.05; CI: 1.02-1.08), lower socioeconomic status (HR: 2.1; CI: 1.02-4.40), and lower educational level (HR: 0.36; CI: 0.16-0.78). Predictive factors of gynecological infections were dose of prednisone between 15 and 60mg/d (HR: 2.05; CI: 1.05-3.99) and higher disease activity at baseline (HR: 1.03; CI: 1.01-1.07).

Conclusion: Female gender, older age at diagnosis, lower socioeconomic status, lower educational level, shorter disease duration, lymphopenia, previous infections, lung involvement, higher damage accrual, higher disease activity, dose of prednisone >15mg/d, and Mestizo ethnicity were predictive of at least one type of infection.

Disclosure: V. R. Pimentel-Quiroz, None; M. Ugarte-Gil, None; G. J. Pons-Estel, None; D. Wojdyla, None; M. Cardiel, None; V. Pascual-Ramos, None; I. Garcia-De La Torre, None; L. Barile, None; M. C. Amigo, None; L. H. Silveira, None; M. J. Sauza del Pozo, None; M. Guibert-Toledano, None; G. A. Reyes, None; A. Iglesias-Gamarra, None; G. Vasquez, None; J. Fernando Molina, None; J. A. Gómez-Puerta, AbbVie,BMS, Pfizer, Roche, 8; L. A. Gonzalez, None; R. Chacón-Díaz, None; M. H. Esteva Spinetti, None; I. Abadi, None; E. M. Acevedo-Vásquez, None; J. Alfaro-Lozano, None; I. Segami, None; L. Massardo, None; O. Neira, None; E. Sato, None; E. Bonfa, None, 2; E. Borba, None; G. S. Alarcón, None; B. Pons-Estel, None.

To cite this abstract in AMA style:

Pimentel-Quiroz VR, Ugarte-Gil M, Pons-Estel GJ, Wojdyla D, Cardiel M, Pascual-Ramos V, Garcia-De La Torre I, Barile L, Amigo MC, Silveira LH, Sauza del Pozo MJ, Guibert-Toledano M, Reyes GA, Iglesias-Gamarra A, Vasquez G, Fernando Molina J, Gómez-Puerta JA, Gonzalez LA, Chacón-Díaz R, Esteva Spinetti MH, Abadi I, Acevedo-Vásquez EM, Alfaro-Lozano J, Segami I, Massardo L, Neira O, Sato E, Bonfa E, Borba E, Alarcón GS, Pons-Estel B. Predictive Factors According to Type of Infection in Systemic Lupus Erythematosus Patients: Data from a Multi-Ethnic, Multi-National, Latin-American Cohort [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/predictive-factors-according-to-type-of-infection-in-systemic-lupus-erythematosus-patients-data-from-a-multi-ethnic-multi-national-latin-american-cohort/. Accessed .

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