Session Information
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Many classification criteria sets have for primary Sjšgren’s Syndrome (pSS).We aimed to compare the performance of 3 classification criteria sets for pSS, to determine the agreement between each other and expert opinion and to investigate diagnostic contribution with any combined use of these criteria. For those assessments, American-European Consensus Criteria (AECG), American Collage of Rheumatology (ACR) / Sjšgren International Clinical Alliance (SICCA) criteria and L.S. Martin et.al. criteria named Mathematical model (M.model) had chosen.
Methods: 86 patients(F:96%,mean age:51.7±11.8) with the diagnosis of pSS were enrolled to the study.Expert opinion had been taken as gold standard for pSS diagnosis.Patients were questioned for eye/mouth dryness.Antinuclear antibody ,complement,anti-Ro-La,serum protein electrophoresis,rheumatoid factor,break-up time (BUT) and Schirmer,minor salivary gland biopsy results were analysed cautiously.The aforementioned criteria sets, were implemented to assess the classification.The percentage of exact agreement and Kappa test was calculated.
Results: Number of patients classified as pSS according to ACR/SICCA, AECG and M.model criteria were 75 (87%), 63 (73%) and 58(67%) respectively. 9 patients (10%) did not fulfill any of these 3 criteria but they were diagnosed as pSS according to expert opinion (Figure1)The Kappa test was moderate between the ACR/SICCA and AECG criteria and slightly low between the M.model with the AECG and ACR/SICCA criteria (Table 1). According to our proposed combination model, number of patients classified as pSS, either AECG or M.model was 74; either AECG or ACR/SICCA model was 76; either ACR/SICCA or M.model was 77(Table 2). In the triple combination of our model, if all 3 criteria used concomitantly, only 46 of patients fulfill the criteria simultaneously; however if any of 3 criteria sets used 77patients fulfill as pSS.
Conclusion: In this study, ACR/SICCA classification criteria for pSS was found the most compatible criteria set with expert opinion.
Table 1.The agreement between three pSS classification criteria sets.(%, Kappa test)
|
AECG |
ACR/SICCA |
M.MODEL |
|
|
AECG |
%83 K:0.50 |
%68 K:0.25 |
|
|
ACR/SICCA |
%83 K:0.50 |
%75 K:0.34 |
|
|
M.MODEL |
%68 K:0.25 |
%75 K:0.34 |
Table 2. Number of patients fulfilling classification criteria
|
Classsification criteria (n) (%)
|
|||
|
According to 1 criteria
|
ACR/SICCA AECG M.model |
75 63 58 |
87,2 73,2 67,4 |
|
According to either of 2 criteria
|
ACR/SICCA or M.model AECG or ACR/SICCA AECG or M. model
|
77 76 74 |
89,5 88,3 86 |
|
According to either of 3 criteria
|
AECG or ACR/SICCA or M.model
|
77 |
89,5 |
To cite this abstract in AMA style:
Kosuva Ozturk Z, Kenar G, Yarkan H, Zengin B, Can G, Onen F, Birlik M. The Performance of Different Classification Criteria in Patients with Primary Sjogren’s Syndrome and Analysis of Their Contribution for Definitive Diagnosis, When Either Criteria Used Alone or in Combination [abstract]. Arthritis Rheumatol. 2017; 69 (suppl 10). https://acrabstracts.org/abstract/the-performance-of-different-classification-criteria-in-patients-with-primary-sjogrens-syndrome-and-analysis-of-their-contribution-for-definitive-diagnosis-when-either-criteria-used-alone-or-in-com/. Accessed .« Back to 2017 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-performance-of-different-classification-criteria-in-patients-with-primary-sjogrens-syndrome-and-analysis-of-their-contribution-for-definitive-diagnosis-when-either-criteria-used-alone-or-in-com/