Background/Purpose: Chondrocalcinosis (CC) results from deposition of calcium pyrophosphate dihydrate (CPPD) in articular cartilage. It is a relatively common radiographic finding of the joints, especially the knee. This study investigated the incidence of knee CC and sought to identify the risk factors for the development of knee CC in the general population.

Methods: We used a prospective, ongoing cohort, composed of 5,018 people, which was established in 2001 to investigate the epidemiologic characteristics of major chronic diseases in Korea. The incidence of knee CC was assessed per 1,000 person-years, and the risk factors were explored by Cox proportional hazard regression analyses.

Results: A total of 4,319 patients who did not have knee CC at enrollment, year 2001-2002, were evaluated with a mean follow-up duration of 8.4 years (SD, 4.2 years). The crude incidence of knee CC was 3.19 per 1,000 person-years (women, 3.55; men, 2.70), and the whole cumulative incidence of knee CC was 2.7%. Older age (≥ 55 years) and higher HbA1C were associated with increased risk of knee CC.

Conclusion: This is the first study to report the incidence of knee CC in the general population. Older age and high HbA1C were independent risk factors for development of knee CC.

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/the-incidence-of-knee-chondrocalcinosis-and-its-risk-factors-in-community-based-cohort/