Differences and Associated Factors in General Disability and Hand Disability Between Patients with Rheumatoid Arthritis and Psoriatic Arthritis

Jose Andres Roman Ivorra¹, Óscar Álvarez¹, Jose Ivorra Cortes¹, Javier Navarro Muñoz², Elena Grau Garcia³, Luis Gonzalez Puig¹, Inmaculada Chalmeta Verdejo¹, Carlos Feced Olmos¹, Eztizen Labrador Sanchez¹, Francisco Miguel Ortiz-Sanjuán⁴, Karla Arevalo Ruales¹, Rosa Negueroles Albuixech¹, Jorge Fragio Gil¹, Isabel Martinez Cordellat¹, Jose Luis Valero Sanz¹, Cristina Alcañiz Escandell^1,3, Gema Poveda Marin^1,3, Carmen Najera Herranz¹ and Victoria Fornes Ferrer⁵, ¹Department of Rheumatology, Hospital Universitario y Politecnico La Fe, Valencia, Spain, ²Universidad Católica de Valencia, Valencia, Spain, ³IIS La Fe, Valencia, Spain, ⁴Department of Rheumatology, Hospital Universitario y Politecnico La Fe, Santander, Spain, ⁵Biostatistics Unit. IIS La Fe, Valencia, Spain

Meeting: 2016 ACR/ARHP Annual Meeting

Date of first publication: September 28, 2016

Keywords: Disability, psoriatic arthritis and rheumatoid arthritis (RA)

Session Information

Date: Sunday, November 13, 2016

Title: Rheumatoid Arthritis – Clinical Aspects - Poster I: Clinical Characteristics/Presentation/Prognosis

Session Type: ACR Poster Session A

Session Time: 9:00AM-11:00AM

Background/Purpose: Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) are well-known disabling conditions, with high impact on patients functioning and quality of life. However, little is published about the differences in disability between RA and PsA patients. The aim of this study was to evaluate and compare general functional disability and specific hand disability in patients with RA and PsA.

Methods: A cross-sectional study was performed. Consecutive patients with RA and PsA attended in a hospital were selected and their medical records reviewed. Sociodemographic and clinical variables including disease duration and activity (DAS28), physical function (Health Assessment Questionnaire, HAQ), handgrip strength in both hands (using an isometric hand dynamometer), radiographic damage (modified Sharp/van der Heijde score (SHS)), and pharmacological treatments were collected following a standardized protocol. Descriptive and bivariate analyses were performed. Multivariate linear regression models completed were to assess disability associated factors.

Results are expressed as coefficient (coef) and 95% confidence interval (CI). Results: A total of 103 RA patients (82.5% were women, mean disease duration 16 years, mean HAQ 1.29, mean DAS28 3.61, mean SHS 45.81, mean grip strength of the right hand 11.22, mean grip strengh of the left hand 11.02, 60.8% on biologic therapy) and 94 patients with PsA (82.5% were women, mean disease duration 14 years, mean HAQ 0.57, mean DAS28 2.7, mean SHS 7.8, mean grip strength of the right hand 20.79, mean grip strength of the left hand 20.06, 51,1% on biologic therapy) were analyzed. Compared to PsA, RA patients were significantly more active, presented more damage and worse grip strength in both hands. Slightly differences were found between disease in the disease duration (p=0,020). In the multivariate regression analyses, poorer function (HAQ score) was associated with RA (compared with PsA) coef=0.24 (95% CI 0.04-0.45), female sex coef=0.37 (95% CI 0.16-0.57), DAS28 coef=0.23 (95% CI 0.16-0.31), and SHS, but not with disease duration. The same results were obtained when the handgrip strength (in each hand separately) were entered in the regression models.

Conclusion: In our study RA patients presented more general and hand disability compared to PsA patients. Other factors as female sex are also associated with poorer function.

Disclosure: J. A. Roman Ivorra, None; Ó. Álvarez, None; J. Ivorra Cortes, None; J. Navarro Muñoz, None; E. Grau Garcia, None; L. Gonzalez Puig, None; I. Chalmeta Verdejo, None; C. Feced Olmos, None; E. Labrador Sanchez, None; F. M. Ortiz-Sanjuán, None; K. Arevalo Ruales, None; R. Negueroles Albuixech, None; J. Fragio Gil, None; I. Martinez Cordellat, None; J. L. Valero Sanz, None; C. Alcañiz Escandell, None; G. Poveda Marin, None; C. Najera Herranz, None; V. Fornes Ferrer, None.

To cite this abstract in AMA style:

Roman Ivorra JA, Álvarez Ó, Ivorra Cortes J, Navarro Muñoz J, Grau Garcia E, Gonzalez Puig L, Chalmeta Verdejo I, Feced Olmos C, Labrador Sanchez E, Ortiz-Sanjuán FM, Arevalo Ruales K, Negueroles Albuixech R, Fragio Gil J, Martinez Cordellat I, Valero Sanz JL, Alcañiz Escandell C, Poveda Marin G, Najera Herranz C, Fornes Ferrer V. Differences and Associated Factors in General Disability and Hand Disability Between Patients with Rheumatoid Arthritis and Psoriatic Arthritis [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). https://acrabstracts.org/abstract/differences-and-associated-factors-in-general-disability-and-hand-disability-between-patients-with-rheumatoid-arthritis-and-psoriatic-arthritis/. Accessed .

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