Background/Purpose:  Rheumatoid arthritis is a chronic, systemic, autoimmune disease about 5% -%1 of world population affected. Highly reactive oxygen free radicals are believed to be involved in the pathogenesis of the disease. Our aim was to investigate the thiol/disulphide homeostasis, which has an important role in many cellular activities such as antioxidant protection, detoxification, cell growth and apoptosis in patients with rheumatoid arthritis.

Methods:  Twenty female and five male patients diagnosed with RA according to American College of Rheumatology 1987 classification criteria and healthy, age, weight and height-matched 20 women and 5 men were evaluated. Disease activity was assessed using a variety of variables including erythrocyte sedimentation rate and C-reactive protein, tender joint count, swollen joint count, and Disease Activity Score-28.

Results: The mean ages of patients group (32.60±7.18) and control group (31.70±8.23) were similar (p=0.573). When we determine at the thiol/disulphide homeostasis parameters in both groups, we can see the mean native thiol (p=0.004), and native thiol/total thiol (p=0.000) levels is lower in the RA group than the control group. The mean disulphide level (p=0.000) was higher in the RA group than control group. The multiple regression analysis of thiol/disulphide balance and other risk factors was performed. Low thiol levels and high disulphide levels in patients with RA were found to be independent of gender, age and body mass index.

Conclusion:  In this study we have shown that thiol/disulphide homeostasis may be used as a novel oxidative stress marker in patients with rheumatoid arthritis. Further studies are needed to confirm the pathophysiologic role of thiol/ disulphide homeostasis in rheumatoid arthritis

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/can-thioldisulphide-is-a-novel-marker-in-rheumatoid-arthritis/