Background/Purpose: To explore cardiac manifestation of Takayasu arteritis and independent risk factor.

Methods: We retrospectively analyzed manifestations and helpful tests in 55 TA patients.  

Results: Fifty-five patients(55/85,64.7%)with TA complicated by cardiac involvement were seen over 10 years£®The male to female ratio was l©U5.87, and the mean age at onset of TA was 24 years. There was no statistically significant difference between TA with and without cardiac involvement groups in terms of gender,clinical type,cardiac symptoms, except confirmed diagnosis time[36(9,168)months vs 12(6,24)months, P=0.001], chest pain[27.3%(15/55)vs 6.7%(2/30),P=0.023]and blood pressure difference >10 mmHg between right-to-left sides[69.1%(38/55) vs 46.7%(14/30),P=0.043]. Cardiac disease included hypertensive heart disease (30 patients,54.5%),cardiomyopathy(6 patients,10.9%),valvular disease(36 patients,65.5%),coronary artery disease(9 patients,16.4%),and pulmonary hypertension (7 patients,12.7%)£®At onset age in patients renal artery involvement was significantly younger in hypertensive heart disease[(28±14)years vs(44±14)years,P=0.006]. LVEF[(34±8)% vs(66±7)%, P=0.000]and age at onset [(15±13)years vs(25±11)years, P=0.030] were statistically significant between patients in TA with and without cardiomyopathy. Multivariate analysis showed that higher CRP was independent risk factor for pulmonary hypertension(OR=0.082,95%CI:0.007-0.965,P=0.047),mitral valve regurgitation(OR=0.192,95%CI:0.040-0.929,P=0.031)and tricuspid regurgitation(OR=0.093,95%CI:0.011-0.761,P=0.018).

Conclusion: We should pay attention to cardiac manifestation of Takayasu’s Arteritis complicated by cardiac involvement to improve its early diagnosis.

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ACR Meeting Abstracts - https://acrabstracts.org/abstract/cardiac-manifestation-of-takayasu-arteritis/