Session Information
Date: Tuesday, November 10, 2015
Title: Systemic Sclerosis, Fibrosing Syndromes and Raynaud's - Clinical Aspects and Therapeutics Poster III
Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose:
UCLA Scleroderma Clinical Trial Consortium Gastrointestinal Tract (UCLA SCTC GIT 2.0) Instrument is a comprehensive, self-administered survey for the assessment of gastrointestinal involvement in patients with systemic sclerosis (SSc), developed and validated in English. This study aimed to translate and validate a Romanian version of the UCLA SCTC GIT 2.0.
Methods:
Translation from English into Romanian has been performed by the forward-backward method. Sixty-four patients with SSc satisfying the 2013 ACR/EULAR classification criteria, attending a referral centre as part of an extensively studied cohort, have been approached in a consecutive manner for administration of the questionnaire. We evaluated the internal consistency, construct validity and discriminative capacity of the translated questionnaire (Romanian GIT). Reproducibility was assessed by retesting the questionnaire over a period of 8-14 days in patients who did not suffer any significant intervention during this time.
Results:
Fifty-four patients (91% females, mean age 52.4±12.1 years, median [range] of disease duration since first non-Raynaud symptom 78.5 [43-148] months, diffuse cutaneous SSc 26%) returned completed questionnaires. The median total GIT score [range] was 0.35 [0-1.51]. Internal consistency was demonstrated by Cronbach’s alpha coefficient (0.931); for all subscales Cronbach’s alpha was ≥0.7, with the exception of the diarrhea subscale (alpha=0.581). Construct validity was supported by moderate, but significant correlations (Spearman) of the Romanian GIT total score with the Mental Component Summary (MCS) of SF-36 (r=0.541) and among subscales, by significant correlations with the Scleroderma Health Assessment Questionnaire (SHAQ) total score (r=0.559) and a strong correlation with the gastrointestinal subscale of the SHAQ (r=0.726). Reproducibility was good with correlation indices >0.7. Divergent validity was supported by significant differences between patients with or without a clinical diagnosis of gastrointestinal disease (see table).
|
Romanian GIT scores and total SHAQ score for patients with/without clinical diagnosis of gastrointestinal (GI) disease |
|||
|
|
No GI diagnosis |
≥1 GI diagnosis |
p |
|
Reflux
|
0.250 (0.125-0.375) |
0.625 (0.250-1.375) |
0.016 |
|
Distension/ bloating |
0.500 (0.000-1.000) |
1.000 (0.500-1.625) |
0.012 |
|
Fecal soilage
|
0.000 (0.000-0.000) |
0.000 (0.000-0.000) |
1.000
|
|
Diarrhea
|
0.000 (0.000-0.000) |
0.000 (0.000-0.500) |
0.021 |
|
Social Functioning
|
0.000 (0.000-0.330) |
0.245 (0.000-0.660) |
0.022 |
|
Emotional well-being |
0.000 (0.000-0.550) |
0.550 (0.000-1.550) |
0.021 |
|
Constipation
|
0.250 (0.000-0.750) |
0.500 (0.000-1.000) |
0.208
|
|
Total GIT score
|
0.221 (0.042-0.378) |
0.589 (0.221-0.839) |
0.002 |
|
SHAQ total score (0-3) |
0.884 (0.385-1.154) |
1.154 (0.653-1.500) |
0.160 |
Medians and interquartile ranges (25-75th percentiles). p values <0.05 are considered significant (Mann-Whitney U test).
Conclusion: The Romanian GIT has acceptable reliability and validity. This questionnaire can be used for the assessment of gastrointestinal involvement in patients wih SSc.
To cite this abstract in AMA style:
Gorga M, Soare A, Dobrota R, Gherghe AM, Stoica V, Mihai C. A Romanian Version of the University of Californa at Los Angeles Scleroderma Clinical Trial Consortium Gastrointestinal Tract (UCLA SCTC GIT 2.0) Instrument [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/a-romanian-version-of-the-university-of-californa-at-los-angeles-scleroderma-clinical-trial-consortium-gastrointestinal-tract-ucla-sctc-git-2-0-instrument/. Accessed .« Back to 2015 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/a-romanian-version-of-the-university-of-californa-at-los-angeles-scleroderma-clinical-trial-consortium-gastrointestinal-tract-ucla-sctc-git-2-0-instrument/