ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 2884

Epidemiological Parameters Affecting Therapeutic Response in Psoriatic Arthritis Patients

Michail P. Migkos1, George Somarakis2, Evripidis Kaltsonoudis3, Theodora E. Markatseli4, Paraskevi V. Voulgari5,6 and Alexandros A. Drosos7, 1Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Fellow in Rheumatology, Ioannina, Greece, 2Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, University of Ioannina, Rheumatology Clinic, Ioannina, Greece, 3Rheumatology Clinic, Department of Internal Medicine, Rheumatologist, Ioannina, Greece, 4Rheumatology Clinic, Department of Internal Medicine, Fellow in Rheumatology, Ioannina, Greece, 5Rheumatology Clinic, Department of Internal Medicine, Assistant Professor of Rheumatology, Ioannina, Greece, 6Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Assistant Professor of Rheumatology, Ioannina, Greece, 7Rheumatology Clinic, Department of Internal Medicine, Medical School, University of Ioannina, 45110, Professor of Medicine/Rheumatology, Ioannina, Greece

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: ,

Session Information

Date: Tuesday, November 10, 2015

Title: Spondylarthropathies and Psoriatic Arthritis - Clinical Aspects and Treatment Poster III: Therapy

Session Type: ACR Poster Session C

Session Time: 9:00AM-11:00AM

Background/Purpose: Published data have shown that epidemiological parameters such as Body Mass Index (BMI), gender and disease duration may affect the therapeutic response in psoriatic arthritis patients receiving disease modifying antirheumatic drugs (DMARDs) conventional or biologic. 

Methods: We retrospectively studied 260 patients diagnosed with psoriatic arthritis (PsA) fulfilling the Assessment of SpondyloArthritis international Society (ASAS) criteria for those with axial involvement and additionally the Classification Criteria for Psoriatic Arthritis (CASPAR) for those with peripheral joint involvement. We studied the effect of BMI, gender, disease duration, and treatment in therapeutic response. The patients were followed up at predefined time points (baseline, 6 months, 1 and 5 years). The treatment response was assessed by using Bath Ankylosing Spondylitis Activity Index (BASDAI), Bath Ankylosing Spondylitis Functionality Index (BASFI), Disease Activity Score in 28 joints-CRP (DAS28-CRP), Disease Activity Score in 28 joints -TKE (DAS28-TKE) and Health Assessment Questionnaire (HAQ). Τhe patients were categorized in two groups according their treatment: group A patients treated with biological DMARDs (anti-TNFa agents) and group B patients treated with conventional DMARDs (methotrexate, leflunomide, cyclosporine). 

Results: Disease duration was positively correlated in all time points (p<0,005) with all disease activity scores (BASDAI, BASFI, DAS28-CRP, DAS28-TKE and HAQ). Statistical significant differences with respect to gender were observed for DAS28-CRP (3,055 – 2,616 p=0,015) and DAS28-TKE (3,543 – 2,640 p<0,0001) at 6 months. More specifically, females showed significant higher DAS28-TKE and DAS28-CRP than males in all cases. BMI was not significantly correlated with the disease activity (BASDAI, BASFI, DAS-CRP, DAS-TKE, HAQ) at any time point. Finally the two treatment groups did not differ significantly with respect to disease activity scores at any time point. 

Conclusion: In the current study longer disease duration was associated with higher disease activity. Females showed higher DAS28-CRP and DAS28-TKE scores than males early on the disease course. BMI as well as treatment options did not show any significant effect in the therapeutic response.

Disclosure: M. P. Migkos, None; G. Somarakis, None; E. Kaltsonoudis, None; T. E. Markatseli, None; P. V. Voulgari, None; A. A. Drosos, None.

To cite this abstract in AMA style:

Migkos MP, Somarakis G, Kaltsonoudis E, Markatseli TE, Voulgari PV, Drosos AA. Epidemiological Parameters Affecting Therapeutic Response in Psoriatic Arthritis Patients [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/epidemiological-parameters-affecting-therapeutic-response-in-psoriatic-arthritis-patients/. Accessed .

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