Session Information
Date: Tuesday, November 10, 2015
Title: Health Services Research Poster III: Patient Reported Outcomes, Patient Education and Preferences
Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: A change of 0.25 in HAQ score has been considered as clinically meaningful. This study is to evaluate the clinical meaningfulness of the HAQ change from health economic perspectives in patients with rheumatoid arthritis using real-world data.
Methods: This is a retrospective cross-sectional study using data in ADELPHI Disease-Specific Program collected in 2014 (EU5 and US). Patients with clinically diagnosed rheumatoid arthritis (N=1032) were enrolled and completed self-reported outcomes measures including physical function by Health Assessment Questionnaire-disability index (HAQ-DI), employment status, work productivity by Work Productivity and Activity Impairment Questionnaire-General Health (WPAI-GH) and general health status by EQ visual analogue scale (EQ VAS). Clinical characteristics include disease activity defined by DAS28. Correlations between HAQ-DI score and other outcomes were analyzed using univariate or multiple regression analysis.
Results: The majority of patients were female (72.1%) with average age of 55 years old and disease duration of about 9 years. The mean (SD) HAQ-DI score was 0.76 (0.69) with 42.2% having a HAQ-DI score ≥ 1, indicating moderate to severe physical disability. 58% of patients were currently unemployed. Patients with a HAQ-DI score of >1.0, 77% were unemployed with a EQ VAS of 54.2, while patients with normal HAQ score of ≤0.5, 40% were unemployed with a EQ VAS of 75.6. HAQ-DI score was significantly correlated with the unemployed in multivariate logistic regression model (p<0.001), and correlated with time lost from work (p<0.001) and general health status by EQ VAS (p<0.001) by multivariate linear regression model. After adjustment for demographic characteristics including age, gender, and disease duration, an 0.25 increase in HAQ-DI score was associated with a 30% increase in likelihood for unemployed status ( OR=1.30, 95% CI=1.22, 1.39).
Conclusion: Physical function measured by HAQ-DI is a valid measure to predict employment status and general health status in patients with rheumatoid arthritis.
To cite this abstract in AMA style:
Han C, Li N, Peterson S. Minimal Important Difference in HAQ: A Validation from Health Economic Perspectives in Patient with Rheumatoid Arthritis Using Real-World Data [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/minimal-important-difference-in-haq-a-validation-from-health-economic-perspectives-in-patient-with-rheumatoid-arthritis-using-real-world-data/. Accessed .« Back to 2015 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/minimal-important-difference-in-haq-a-validation-from-health-economic-perspectives-in-patient-with-rheumatoid-arthritis-using-real-world-data/