Session Information
Date: Monday, November 9, 2015
Title: Spondylarthropathies and Psoriatic Arthritis - Comorbidities and Treatment Poster II
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose:
To study the effect of the presence of fibromyalgia (FMS) on common clinical disease activity indices in patients with psoriatic arthritis (PsA).
Methods:
Seventy –three consecutive outpatients with PsA (mean age 51.7 years old;
42 females, 57.5 %) were enrolled in a prospective cross-sectional study.
Patients were evaluated for the presence of fibromyalgia according to the ACR criteria. In parallel, they all underwent a clinical evaluation of diseases activity as well as application of patient reported outcomes questionnaires including HAQ, BASDAI, and DLQI. Disease activity was evaluated using the Composite Psoriatic Disease Activity Index (CPDAI), Minimal Disease Activity (MDA) and Disease Activity index for Psoriatic Arthritis (DAPSA) scores.
Results:
The overall prevalence of FMS was 17.8% (13 patients), with a significant higher prevalence of female gender (12 patients, 92.3%, P = 0.005). CPDAI and DAPSA scores were significantly higher in patients with PsA and FMS (9.23 ± 1.92; 27.53 ± 19.23) than in patients with PsA alone (4.25 ± 3.14; 12.82 ± 12.71; P < 0.001; P = 0.003). None of the patients with FMS complied with the criteria of MDA, whereas twenty-six PsA-only patients complied with it (43.3%, P = 0.003). HAQ, BASDAI and LEI scores were significantly worse in patients with PsA and associated FMS (Table 1).
Conclusion:
FMS is related to worse scores on the CPDAI, DAPSA, MDA, HAQ, BASDAI and LEI in patients with PsA. The presence of FMS distorts our clinical understanding of the abovementioned indices, thus, it should be taken into consideration in the treatment algorithm in order to avoid unnecessary upgrading of treatment.
Table 1.
|
Indices |
PsA |
PsA and FMS |
|
|
(n = 60) |
(n = 13, 17.8%) |
Pv |
|
|
CPDAI ± SD |
4.25 ± 3.14 |
9.23 ± 1.92 |
< 0.001 |
|
DAPSA ± SD |
12.82 ± 12.7 |
27.53 ± 19.23 |
0.003 |
|
MDA (%) |
26 (43.3%) |
0 |
0.003 |
|
HAQ median |
0.25 (0-1) |
1.75 (1.07-2.37) |
<0.001 |
|
BASDAI±SD |
2.87± 2.35 |
7.18±1.73 |
<0.001 |
|
LEI median |
0 (0-1) |
3 (2-4) |
<0.001 |
|
PASI |
2.1 (0-1) |
3 (2-4) |
0.22 |
To cite this abstract in AMA style:
Brikman S, Furer V, Wolman Y, Borok Lev-Ran S, Polachek A, Elalouf O, Sharabi A, Kaufman I, Paran D, Elkayam O. Cross Sectional Study Investigating the Effect of the Presence of Fibromyalgia on Common Clinical Disease Activity Indices in Patients with Psoriatic Arthritis [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/cross-sectional-study-investigating-the-effect-of-the-presence-of-fibromyalgia-on-common-clinical-disease-activity-indices-in-patients-with-psoriatic-arthritis/. Accessed .« Back to 2015 ACR/ARHP Annual Meeting
ACR Meeting Abstracts - https://acrabstracts.org/abstract/cross-sectional-study-investigating-the-effect-of-the-presence-of-fibromyalgia-on-common-clinical-disease-activity-indices-in-patients-with-psoriatic-arthritis/