Prevalence of Co-Morbidities and Evaluation of Their Monitoring in Korean Patients with RA: Comparison with the Results of an International, Cross-Sectional Study (COMORA)

In Ah Choi¹, Sung-Hwan Park², Hoon-Suk Cha³, Won Park⁴, Hyun Ah Kim⁵, Dae-Hyun Yoo⁶, Han Joo Baek⁷, SeungGeun Lee⁸, Yoon Jong Lee⁹, Yong Bum Park¹⁰, Seung-Cheol Shim¹¹, Ihsane Hmamouchi¹² and Yeong Wook Song¹³, ¹Rheumatology, Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, Seoul, South Korea, ³Division of Rheumatology, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea, ⁴Division of Rheumatology, Department of Internal Medicine, Inha University Hospital, Incheon, South Korea, ⁵Division of Rheumatology, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, South Korea, ⁶Division of Rheumatology, Department of Internal Medicine, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, ⁷Rheumatology, Gachon University Gil Medical Center, Incheon, South Korea, ⁸Division of Rheumatology, Department of Internal Medicine, Pusan Nationl University Hospital, Busan, South Korea, ⁹Division of rheumatology Seoul National University Bundang Hospital, Seongnam, South Korea, ¹⁰Division of Rheumatology, Department of Internal Medicine, Yoesei University Severance Hospital, Seoul, South Korea, ¹¹Division of Rheumatology, Department of Internal Medicine, Eulji University Hospital, Daejeon, South Korea, ¹²El Ayachi Hospital, Rabat, Morocco, ¹³Division of Rheumatology, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea

Meeting: 2015 ACR/ARHP Annual Meeting

Date of first publication: September 29, 2015

Keywords: Comorbidity and rheumatoid arthritis (RA)

Session Information

Date: Monday, November 9, 2015

Title: Rheumatoid Arthritis - Clinical Aspects Poster II

Session Type: ACR Poster Session B

Session Time: 9:00AM-11:00AM

Background/Purpose: Rheumatoid Arthritis (RA) patients are at increased risk of developing co-morbid conditions. We designed this study to evaluate the prevalence of comorbidities and their monitoring in Korean RA patients compared with the patients from other countries.

Methods: We analyzed the demographics, disease characteristics, comorbidities and their monitoring states of 1050 RA patients from 11 Korean centers and compared with those of 3520 patients from 16 other countries using COMORA database.

Results:

The prevalence of obese patients was significantly lower and married patients was higher in Korean patients (p<0.0001, both). Disease duration was shorter, uses of prednisolone and NSAIDs were more frequent and the use of biologics was lower in Korean patients (p<0.0001, all). The prevalence of cardiovascular (CV) event was not significantly different between two groups. The prevalence of basocellular skin cancer was significantly lower in Korean patients (p<0.0001).

The proportion of current smoker, patients who have a family history of CV disease, hyperlipidemia and patients with Framingham score >20% were significantly lower, although the prevalence of diabetes was higher in Korean patients (p<0.0001, all).

Annual evaluation of CV risk was less frequently performed in Korean (p=0.0011) although the use of antiplatelet agent was more frequent (p=0.0004). Prostatic and skin cancer monitoring were less frequently performed (p<0.0001) but lung and breast cancer monitoring were more frequently performed (p=0.048 and p<0.0001). Vitamin D supplement was less frequently used (p<0.0001).

When we analyzed the association of GI disease with medication, the risk of GI ulcer was increase with prednisolone (Odds ratio 1.68, 95% CI 1.34-2.09) and NSAIDs (odds ratio 1.44, 95% CI 1.16-1.79) in patients from other countries. The usage of NSAID was protective for the development of colon cancer in RA patients of Korea (odds ratio 0.09, 95% CI 0.01-0.86) and other countries (odds ratio 0.3, 95% CI 0.12-0.75). The usage of biologic agents increased the risk of lymphoma in countries other than Korea (odds ratio 19.08, 95% CI 2.51-145.27).

Conclusion: There are differences in the prevalence of co-morbidities and monitoring states of the risk factors between patients in Korea and the other countries. The prevalence of CV morbidity was similar between two groups although the prevalence of CV risk factors is significantly low in Korean, suggesting more attention to yearly CV risk monitoring is needed. The usage of NSAID was protective for the development of colon cancer in RA patients of Korea and other countries.

Disclosure: I. A. Choi, None; S. H. Park, None; H. S. Cha, None; W. Park, None; H. A. Kim, None; D. H. Yoo, None; H. J. Baek, None; S. Lee, None; Y. J. Lee, None; Y. B. Park, None; S. C. Shim, None; I. Hmamouchi, None; Y. W. Song, None.

To cite this abstract in AMA style:

Choi IA, Park SH, Cha HS, Park W, Kim HA, Yoo DH, Baek HJ, Lee S, Lee YJ, Park YB, Shim SC, Hmamouchi I, Song YW. Prevalence of Co-Morbidities and Evaluation of Their Monitoring in Korean Patients with RA: Comparison with the Results of an International, Cross-Sectional Study (COMORA) [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/prevalence-of-co-morbidities-and-evaluation-of-their-monitoring-in-korean-patients-with-ra-comparison-with-the-results-of-an-international-cross-sectional-study-comora/. Accessed .

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