ACR Meeting Abstracts

ACR Meeting Abstracts

Abstract Number: 1341

Beneficial Effect of Anti-TNF Therapy in the Lipoprotein Atherogenic Risk Profile in Comparison with DMARD Standard Therapy in RA Patients

Jaime Calvo-Alen1, Ignacio Villa2, Victor M. Martinez-Taboada3, Jose Luis Peña-Sagredo4, Mario Agudo4, Ana Carmen García5 and Juan Gomez-Gerique6, 1Rheumatology, Hospital de Sierrallana. Torrelavega. Spain, Torrelavega, Spain, 2Rheumatology, Hospital Universitario Sierrallana, Torrelavega, Spain, 3Rheumatology, Hospital Universitario Marques de Valdecilla. IFIMAV, Santander, Spain, 4Rheumatology, Hospital Universitario Marqués de Valdecilla. IFIMAV, Santander, Spain, 5Fundación 12 de Octubre, Madrid, Spain, 6Laboratorio de metabolismo lípidico y riesgo vascular, Hospital Universitario Marqués de Valdecilla, Santander, Spain

Meeting: 2012 ACR/ARHP Annual Meeting

Keywords: ,

Session Information

Title: Rheumatoid Arthritis Treatment - Small Molecules, Biologics and Gene Therapy

Session Type: Abstract Submissions (ACR)

Background/Purpose: RA patients portend a greater risk of cardio-vascular complications than general population. Although most probably diverse mechanisms are implicated, quantity and quality changes in the lipoproteins appear to have an important role.

Methods: RA patients in stable treatment with anti-TNF therapy at least during the last six months and a matched (by age, gender and rheumatoid factor status) with stable doses of standard DMARDs (most of them using methotrexate) were clinically evaluated using DAS28, as activity marker and MHAQ to assess disability. In addition, a complete standard lipid profile, a comprehensive lipoprotein assessment was carried out including: Lipoprotein, and apolipoprotein A1 (ApoA1) and B ( ApoB) levels (total and lipoprotein specific), levels of paroxonase 1 (PON1), HDL, LDL, VLDL and total cholesterol, triglycerides and phospholipids levels as well as number of molecules of these lipids  (mc, mt and mf respectively) in each lipoprotein, total mass  (M) and number of particles (np) of the before mentioned lipoproteins, levels of PCSK9 receptor. Results of both subsets of patients were performed with standard statistical tests.

Results: 

Sixty-seven RA patients on anti-TNF and 63 matched RA patients on DMARD, mean age (58.7±12.3 and 61±12.1 years), gender distribution (81% females in both cases), disease duration (140±165 and 143±276 months) and RF status (64% in both cases) were comparable. Patients on DMARD were more active (DAS28 4.42±1.35 vs 3.57± 1.27 and hsCRP 9.4±15.2 vs 3.8±5.8 mg/l respectively. Main findings in the lipoprotein analysis are shown in table 1:

 

Apo-A (mg/dl)

MVLDL (mg/dl)

np VLDL

Anti-TNF

169.7

913.5

89513.1

DMARD

156.2

1360.8

112898.3

p value

.008

.001

.017

Multivariate analysis were performed with the three variables entering DAS28 as covariate and in all cases anti-TNF therapy remained as unique explicative variable.

Conclusion:

RA patients treated with anti-TNF, regardless that they show lower levels of clinical activity, they have an improvement in their atherogenic risk profile showing higher levels of ApoA1 and therefore greater antioxidant capacity as well as lower levels of total mass and number of particles of VLDL which are atherogenic risk factors.

Disclosure:

J. Calvo-Alen,
None;

I. Villa,
None;

V. M. Martinez-Taboada,
None;

J. L. Peña-Sagredo,
None;

M. Agudo,
None;

A. C. García,
None;

J. Gomez-Gerique,
None.

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