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Abstract Number: 1155 • ACR Convergence 2025
Zasocitinib (TAK-279), an Investigational, Oral, Allosteric, Selective TYK2 Inhibitor, in Moderate-to-Severe Plaque Psoriasis: Efficacy Analysis by Baseline Characteristics from a Randomized Phase 2b Trial
Nada Elbuluk¹, Melinda J. Gooderham², Jessamyn Blau³, Wenwen Zhang³, Ejim Mark³, Warren Winkelman³ and Mark Lebwohl⁴, ¹Department of Dermatology, USC Keck School of Medicine, Los Angeles, CA, ²SKiN Centre for Dermatology, Queen's University, & Probity Medical Research, Peterborough, ON, ON, Canada, ³Takeda Development Center Americas, Inc., Cambridge, MA, ⁴Icahn School of Medicine at Mount Sinai, New York, NY
Background/Purpose: Zasocitinib (TAK-279) is an investigational, highly selective and potent, oral, allosteric tyrosine kinase 2 (TYK2) inhibitor. In a phase 2b trial of moderate-to-severe plaque…
Abstract Number: 1155 • ACR Convergence 2024
Stratification of Cancer Risk in Idiopathic Inflammatory Myopathies. Application of the IMACS Guidelines to Enhance Screening
Miriam Retuerto Guerrero¹, Clara Moriano², cristiana sieiro santos³ and elvira Diez álvarez⁴, ¹Complejo Asistencial Universitario de León, Leon, Spain, ²Hospital León, LEON, Spain, ³Rheumatology Department, Complejo Asistencial Universitario de León, León, Spain, Leon, Spain, ⁴Complejo Asistencial Universitario de Leon, Leon
Background/Purpose: Idiopathic inflammatory myopathies (IIM) carry an elevated risk of cancer incidence. Recently published International Guidelines for IIM-associated cancer screening from the Myositis Assessment and…
Abstract Number: 1155 • ACR Convergence 2023
Identification of Serum Biomarkers Associated with Muscle Damage Detected on MRI in Polymyositis/dermatomyositis
Haruna Matsuo¹, Toshimasa Shimizu², Tomohiro Koga³, Nozomi Oki⁴, Mari Kamiya⁵, Natsuka Umezawa⁵, Shinsuke Yasuda⁶, Masataka Uetani⁷ and Atsushi Kawakami⁸, ¹Nagasaki University, Nagasaki City, Japan, ²Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ³Department of Immunology and Rheumatology, Division of Advanced Preventive Medical Sciences, Nagasaki University, Nagasaki, Japan, ⁴Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki City, Japan, ⁵Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, ⁶Department of Rheumatology, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University (TMDU), Tokyo, Japan, ⁷Department of Radiological Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, ⁸Nagasaki University, Nagasaki, Japan
Background/Purpose: Polymyositis/Dermatomyositis (PM/DM) is a chronic inflammatory disease characterized by muscle weakness, and cutaneous manifestations. Although PM/DM exhibits distinct disease phenotypes based on autoantibodies, assessing…
Abstract Number: 1155 • ACR Convergence 2022
Epigenome-Wide Integrative Association Study on Spondyloarthritis and Psoriatic Arthritis
Elena Carnero-Montoro¹, Ivan Arias-de la Rosa², Clementina Lopez-Medina³, lourdes Ladehesa-Pineda⁴, Rafaela Ortega-Castro², Daniel Toro-Domínguez¹, Manuel Martinez-Bueno¹, Raúl López-Domínguez⁵, Olivia Castellini-Pérez¹, Guillermo Barturen¹, Nuria Barbarroja², Eduardo Collantes² and Marta Alarcon-Riquelme¹, ¹Center for Genomics and Oncological Research (GENYO), Granada, Spain, ²IMIBIC/University of Cordoba/Reina Sofia Hospital, Cordoba, Spain, ³Reina Sofia University Hospital, Rheumatology Department, Jaén, Spain, ⁴Reina Sofia University Hospital/Rheumatology Department/Maimonides Institute for Biomedical Research (IMIBIC), Cordoba, Spain, ⁵University of Granada, Granada, Spain
Background/Purpose: An important role of DNA methylation changes in Spondylitis Ankylosing has been recently demonstrated by epigenome-wide studies. However, there is a lack of genome-wide…
Abstract Number: 1155 • ACR Convergence 2021
Pregnancy Experiences and Unmet Needs for Women of Childbearing Age with Chronic Rheumatic Disease in China
xinping tian¹ and yongfei fang², ¹Peking Union Medical College Hospital, beijing, China (People's Republic), ²The First Hospital Affiliated to AMU (Southwest Hospital), Chongqing, China (People's Republic)
Background/Purpose: Recent European research on patients with chronic rheumatic diseases (CRDs) revealed that women of childbearing age (WoCBA) have many fears and misconceptions about their…
Abstract Number: 1155 • ACR Convergence 2020
Long-term Safety Profile of Anakinra in Patients with Systemic Juvenile Idiopathic Arthritis
Gabriella Giancane¹, Riccardo Papa¹, Sebastiaan Vastert², Francesca Bagnasco¹, Joost Swart¹, Pierre Quartier³, Jordi Anton⁴, Isabelle Kone Paut¹, Sylvia Kamphuis¹, Troels Herlin⁵, Helga Sanner¹, Fabrizio De Benedetti⁶, Elena Tsitsami⁷, Susan Mary Nielsen¹, Estefania Moreno¹, Chiara Pallotti¹, Karin Franck-Larsson⁸, Håkan Malmström⁸, Susanna Cederholm⁹, Nico Wulffraat¹ and Nicolino Ruperto¹⁰, ¹IRCCS Istituto Giannina Gaslini, PRINTO, Genoa, Italy, Genova, Italy, ²University Medical Center Utrecht, Utrecht, Netherlands, ³Necker-Enfants Malades University Hospital, Assistance Publique-Hopitaux de Paris, Paris, France, ⁴Sant Joan de Déu Hospital, Madrid, Spain, ⁵Aarhus University Hospital, Aarhus, Denmark, ⁶Division of Rheumatology, Laboratory of Immuno-Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy, Rome, Italy, ⁷Aghia Sophia Childrens Hospital, Athens, Greece, ⁸Swedish Orphan Biovitrum, Stockholm, Sweden, ⁹Sobi, Stockholm, Sweden, ¹⁰PRINTO, Istituto Giannina Gaslini, Genova, Italy
Background/Purpose: To evaluate the long-term safety profile of anakinra in patients with systemic juvenile idiopathic arthritis (sJIA)Methods: Data from patients with sJIA according to the…
Abstract Number: 1155 • 2019 ACR/ARP Annual Meeting
The Status of Latin-American Women in Rheumatology
Genessis Maldonado¹, Maria Intriago ¹, Enrique Soriano ² and Carlos Rios ¹, ¹Universidad Espiritu Santo, Guayaquil, Ecuador, ²Rheumatology Section, Internal Medicine Service, Hospital Italiano de Buenos Aires, Argentina., Buenos Aires, Buenos Aires, Argentina
Background/Purpose: Currently, Latin America does not have detailed information of women in rheumatologists based on education, working conditions, productivity, distribution of time between work activities…
Abstract Number: 1155 • 2018 ACR/ARHP Annual Meeting
A Collaborative Cardio-Rheumatology Clinic for Primary Prevention of Cardiovascular Diseases – a Descriptive Study
Shadi Akhtari¹, Paula Harvey¹, Micaela Jacobson², Shani Nagler³, Keith Colaco⁴ and Lihi Eder⁵, ¹Cardiology, Women's College Hospital, University of Toronto, Toronto, ON, Canada, ²Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada, ³Women's College Hospital, Toronto, ON, Canada, ⁴Institute of Medical Science, University of Toronto, Toronto, ON, Canada, ⁵Women's College Research Institute, University of Toronto, Women's College Hospital, Toronto, ON, Canada
Background/Purpose: Patients with inflammatory arthritis are at increased risk for atherosclerotic cardiovascular (CV) disease. This has been under-recognized in clinical practice. Additionally, the current risk…
Abstract Number: 1155 • 2017 ACR/ARHP Annual Meeting
Impact of Adalimumab on Immunosuppressant Use in Patients with Active and Inactive Non-Infectious Intermediate, Posterior, or Pan-Uveitis in the Ongoing Open Label Study: Visual-III
Sergio Schwartzman¹, Irene Van der Horst-Bruinsma², Alfredo Adan³, Hiroshi Goto⁴, Koju Kamoi⁵, Martina Kron⁶, Alexandra P. Song⁷, Kevin Douglas⁷, Sophia Pathai⁸ and C. Stephen Foster⁹, ¹Hospital for Special Surgery, New York, NY, ²Department of Rheumatology, VU University Medical Center, Amsterdam, Netherlands, ³Hospital Clinic. Barcelona. Spain, Barcelona, Spain, ⁴Tokyo Medical University, Tokyo, Japan, ⁵Tokyo Medical and Dental University, Tokyo, Japan, ⁶AbbVie Deutschland GmbH & Co. KG, Ludwigshafen, Germany, ⁷AbbVie Inc., North Chicago, IL, ⁸AbbVie Ltd, Maidenhead, United Kingdom, ⁹Massachusetts Eye Research and Surgery foundation and Harvard Medical School, Boston, MA
Background/Purpose: The morbidity associated with the use of immunosuppressants is well described in patients (pts) with autoimmune ophthalmic disease and presents a challenge to treating…
Abstract Number: 1155 • 2016 ACR/ARHP Annual Meeting
The Effect of Nurse-Led Follow-up in Rheumatoid Arthritis. a Systematic Review and Meta-Analysis of Randomized Controlled Trails
Annette de Thurah^1,2, Bente Appel Esbensen^3,4, Ida K Roelsgaard⁴, Tove F Frandsen⁵ and Jette Primdahl^6,7, ¹Department of Rheumatology, Aarhus University Hospital, Aarhus, DK, Aarhus, Denmark, ²Department of Clinical Medicine, Aarhus University, Aarhus, DK, Aarhus N, Denmark, ³Copenhagen Center for Arthritis Research (Copecare), Rigshospitalet, Copenhagen, DK, Copenhagen, Denmark, ⁴Department of Clinical Medicine, University of Copenhagen, Copenhagen, DK, Copenhagen, Denmark, ⁵The knowledge Center of Odense University Hospital, Odense University Hospital, Odense, DK, Odense, Denmark, ⁶King Christian X’s Hospital for Rheumatic Diseases, Graasten, Hospital of Southern Jutland, DK, Graasten, Denmark, ⁷Institute for Regional health Research, University of Southern Denmark, Odense, DK, Odence, Denmark
Background/Purpose: Due to a longer life expectancy in general, the treatment burden of RA is growing, and although treatment is generally becoming more effective and…
Abstract Number: 1155 • 2015 ACR/ARHP Annual Meeting
Free Fatty Acids Promote Inflammation in Bone of Rheumatic Patients Via Osteoblast
Klaus W. Frommer¹, Andreas Schäffler², Uwe Lange^1,3, Stefan Rehart⁴, Jürgen Steinmeyer^5,6, Markus Rickert⁷, Ulf Müller-Ladner^1,8 and Elena Neumann¹, ¹Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Department of Internal Medicine III, Endocrinology, Diabetes, Metabolism, Justus-Liebig-University of Giessen, Bad Nauheim, Germany, ³Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁴Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany, ⁵Experimental Orthopedics, Justus-Liebig-University of Giessen, Giessen, Germany, ⁶Dept Orthopedics and Experimental Orthopedics, University Hospital of Giessen and Marburg, Giessen, Germany, ⁷Dept of Orthopedics and Orthopedic Surgery, University Hospital of Giessen and Marburg, Gießen, Germany, ⁸Internal Medicine/Rheumatology, Justus-Liebig-University of Giessen, Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany
Background/Purpose: A pathophysiological link of free fatty acids (FFA) to inflammation is supported by the observation that chronically elevated serum FFA levels as found in…
Abstract Number: 1155 • 2014 ACR/ARHP Annual Meeting
Economic Impact of Frequent Gout Flares in a Managed Care Setting
Robert Jackson¹, Aki Shiozawa², Erin Buysman³, Aylin Altan³, Stephanie Korrer³ and Hyon K. Choi⁴, ¹Global Medical Office, Takeda Pharmaceuticals International, Inc, Deerfield, IL, ²One Takeda Parkway, Takeda Pharmaceuticals International, Inc, Deerfield, IL, ³Health Economics and Outcomes Research, Optum, Eden Prairie, MN, ⁴Boston University School of Medicine, Boston, MA
Background/Purpose Gout is the most common inflammatory arthritis in the US. For most patients, excruciatingly painful gout attacks (“flares”) are the major clinical burden of…
Abstract Number: 1155 • 2012 ACR/ARHP Annual Meeting
A New Measure of Visual Function for Children with Juvenile Idiopathic Arthritis-Associated Uveitis
Sheila T. Angeles-Han¹, Steven Yeh², Courtney McCracken¹, Larry B. Vogler³, Kelly A. Rouster-Stevens⁴, Christine W. Kennedy⁵, Kirsten Jenkins⁶, Matthew Kent³, Scott Lambert⁷, Carolyn Drews-Botsch⁸ and Sampath Prahalad⁹, ¹Emory University School of Medicine, Atlanta, GA, ²Ophthalmology, Emory University School of Medicine, Atlanta, GA, ³Dept of Pediatrics, Emory Univ School of Medicine, Atlanta, GA, ⁴Pediatric Rheumatology, Emory Univ School of Medicine, Atlanta, GA, ⁵Rheumatology Immunology, Emory Children's Center, Atlanta, GA, ⁶Children's Healthcare of Atlanta, Atlanta, GA, ⁷Ophthalmology, Emory Univ School of Medicine, Atlanta, GA, ⁸Epidemiology, Emory University School of Public Health, Atlanta, GA, ⁹Pediatrics, Emory Children's Center, Atlanta, GA
Background/Purpose: Studies on outcomes of children with juvenile idiopathic arthritis-associated uveitis (JIA-U) focus on the clinical ocular exam and physical disability secondary to arthritis. This…

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