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Abstracts tagged "Adipocytokines"

  • Abstract Number: 1943 • 2017 ACR/ARHP Annual Meeting

    Adipocytokines in an Osteoarthritis Mouse Model

    Marie-Lisa Hülser1, Carina Schreiyäck1, Yubin Luo2, Aline Bozec2, Georg Schett3, Elena Neumann4 and Ulf Müller-Ladner5, 1Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, 2Department Clinic of Medicine 3 - Immunology und Rheumatology, University of Erlangen-Nürnberg, Department Clinic of Medicine 3 - Immunology and Rheumatology, Erlangen, Germany, Erlangen, Germany, 3Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Department of Internal Medicine 3 – Rheumatology and Immunology, Universitätsklinikum Erlangen, Erlangen, Germany., Erlangen, Germany, 4Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, 5Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany

    Background/Purpose: In the Western society adiposity and metabolic syndrome are an increasing field of medical research. Both entities influence the expression of adipokines such as…
  • Abstract Number: 1803 • 2015 ACR/ARHP Annual Meeting

    Serum Adipocyte Fatty Acid-Binding Protein Level Is Elevated in Patients with Systemic Lupus Erythematosus (SLE) but Not Associated with Biophysical Markers of Cardiovascular Disease

    Anselm Mak1,2, Herbert Schwarz3, Nien Yee Kow2, Sen Hee Tay4 and Lieng Hsi Ling2,5, 1National University Health System, Singapore, Singapore, 2Medicine, National University of Singapore, Singapore, Singapore, 3Physiology, National Unversity of Singapore, Singapore, Singapore, 4National University of Singapore, Singapore, Singapore, 5National Unversity Heart Centre Singapore, National Unversity Health System, Singapore, Singapore

    Background/Purpose: Adipocyte fatty acid-binding protein (aFABP) is an intracellular lipid-binding protein expressed in adipocytes and macrophages, particularly in inflammatory conditions. Recently, high circulating serum aFABP…
  • Abstract Number: 332 • 2015 ACR/ARHP Annual Meeting

    Adipokine SERUM Levels in Patients with EARLY Knee Osteoarthritis with and without Metabolic Syndrome

    Istar Guzman1, Rolando Espinosa-Morales2, Ignacio-Alfredo Valerio-Morales3, Austreberto Sanchez1, Paulina P4 and Carlos Lozada1, 1Rheumatology, National Institute of Rehabilitation, Mexico, Mexico, 2Mexican Board of Rheumatology, Mexico City, Mexico, 3Rheumatology, National Institute of Rehablitation, Mexico, Mexico, 4Rheumatology, National institute of Rehabilitation, Mexico, Mexico

    Background/Purpose: Osteoarthritis is a chronic, inflammatory, multifactorial disease. The metabolic syndrome (MS) has been linked to this disease; adipokines levels have been associated in the…
  • Abstract Number: 9 • 2015 ACR/ARHP Annual Meeting

    Serum Visfatin Levels in Patients with Axial Spondyloarthitis and Early Rheumatoid Arthritis: Relation to Inflammation and Bone Changes

    Hana Hulejova1, Klára Prajzlerová2, Olga Krystufkova2, Krystýna Grobelná2, Maria Filkova2, Herman F Mann3, Karel Pavelka4, Jiri Vencovsky3 and Ladislav Senolt5, 1Institute of Rheumatology and Department of Rheumatology, Prague, Czech Republic, 2Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 3Institute of Rheumatology, Prague, Czech Republic, 4Charles University, Prague, Czech Republic, 5Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic

    Background/Purpose: Visfatin may represent a novel biomarker of disease severity. Serum visfatin levels are elevated in patients with early rheumatoid arthritis (ERA) and axial spondyloarthritis…
  • Abstract Number: 2933 • 2014 ACR/ARHP Annual Meeting

    Metabolic Syndrome, Adipocytokines and Inflammation in Sjögren’s Syndrome

    Kristopherson Lustosa Augusto1, Eloisa Bonfá2, Rosa M. R. Pereira1, Cleonice Bueno3, Vilma S. T. Viana4 and Sandra G. Pasoto5, 1Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, 2Rheumatology Division, University of Sao Paulo, Sao Paulo, Brazil, 3Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, 4Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 5Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil

    Background/Purpose Systemic inflammation has been linked to increased frequency of metabolic syndrome (MetS) in autoimmune diseases. However, there are no studies concerning the frequency of…
  • Abstract Number: 532 • 2014 ACR/ARHP Annual Meeting

    Adipose Tissue Is Prominent in Salivary Glands of Sjögren’s Syndrome Patients and Appears to Influence the Autoimmune Microenvironment in These Organs

    Kathrine Skarstein1,2, Lara Adnan Aqrawi3, Roland Jonsson4,5 and Janicke Cecilie Liaaen Jensen6, 1Gade Laboratorium for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, 2Department of Pathology, Haukeland University Hospital, Bergen, Norway, 3Department of Clinical Science, University of Bergen, Bergen, Norway, 4Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, 5Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, 6Department of Oral Surgery and Oral Medicine, University of Oslo, Oslo, Norway

    Background/Purpose A positive salivary gland (SG) biopsy with a focus score of ≥1 is the only widely accepted pathological finding confirming the salivary gland component…
  • Abstract Number: 435 • 2014 ACR/ARHP Annual Meeting

    Smoking Functions As a Negative Regulator of IGF-1 Levels and Adipokine Network in Patients with Rheumatoid Arthritis

    Maria Bokarewa1, Malin Erlandsson2, Sofia Töyrä Silfverswärd3, Andreea Ioan-Fascinay4 and Roberto Doria Medina5, 1Guldhedsgatan 10, University of Goteborg, Goteborg, Sweden, 2Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, 3Rheumatology and Inflammation Research, University of Göteborg, Göteborg, Sweden, 4Rheumatology, Leiden University Medical Center, Leiden, Netherlands, 5University of Göteborg, Göteborg, Sweden

    Background/Purpose Smoking is an important player in the pathogenesis of rheumatoid arthritis (RA) being tightly connected to the genetic (carriage of HLA-DRB1 shared epitope) and…
  • Abstract Number: 2474 • 2013 ACR/ARHP Annual Meeting

    Fat Mass and Resistin: Predictive Factors For Anti-TNF Therapy Response In Ankylosing Spondylitis Patients

    Carla G.S. Saad1, Andressa Silva Abreu1, Ana Cristina Medeiros Ribeiro1, Julio C. B. Moraes2, Luiz A. Perandini1, Thalita Dassouki3, Rosa M. R. Pereira4, Eloisa Bonfa5 and Ana Lucia S. Pinto1, 1Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, 2Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, 3Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, 4Reumatologia, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil, 5Rheumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

    Background/Purpose: The adipose tissue immune properties and pharmacokinetic consequences can contribute to the pathogenesis of inflammatory conditions. The hole of fat tissue in active Ankylosing…
  • Abstract Number: 1397 • 2013 ACR/ARHP Annual Meeting

    Changes In MMP In Fibroblast-Like Synoviocytes Following Adipogenesis

    Satoshi Yamasaki, Kazuhiko Kumagai, Kouji Endo, Takaki Nojima and Eiji Sugiyama, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan

    Background/Purpose:   Fibroblast-like synovial cells (FLS) play important roles in the disease progression of RA. FLS produce cytokines and chemokines that contribute to chronic inflammation…
  • Abstract Number: 727 • 2013 ACR/ARHP Annual Meeting

    Adiponectin Promotes The Differentiation Of naïve T Cell To Th17 Cell and Aggravates Collagen-Induced Arthritis

    Miaojia Zhang1, Xiaoxuan Sun2, Wenfeng Tan3, Xiaoke Feng4 and Ke Gan5, 1Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA., Nanjing, China, 2Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA, Nanjing, China, 3Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, 4Rheumatology, the First Affiliated Hospital of Nanjing Medical University, China, Nanjing, China, 5Rheumatology Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    Background/Purpose: To investigate a role of Adiponectin (AD) on the differentiation of naïve T cell to Th17 cell and bone erosion in collagen-induced arthritis (CIA)…
  • Abstract Number: 599 • 2013 ACR/ARHP Annual Meeting

    Association Between Serum Leptin and Adiponectin Levels With The Severity Of Proteinuria In Lupus Nephritis

    Valeria Diaz-Rizo1, Nicte Selene Fajardo-Robledo2, Alan Joel Ruiz-Padilla2, Dalia Sanchez-Mosco3, Tania Marlene Rodriguez-Hernandez4, Xochitl Trujillo5, Miguel Huerta5, Monica Vazquez del Mercado6, Laura Gonzalez-Lopez4 and Jorge Ivan Gamez-Nava7, 1Doctorado en Ciencias Médicas, Centro Universitario de Investigación Biomédica, Universidad de Colima; UMAE, Hospital de Especialidades, Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jalisco, Mexico, 2Fisiología, Doctorado en Farmacología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, 3Centro Universitario de Investigación Biomédica, Universidad de Colima; Hospital General Regional 110 IMSS, Guadalajara, Jalisco, Mexico, 4Departamento de Medicina Interna/Rheumatología, Hospital General Regional 110, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico, 5Centro Universitario de Investigación Biomédica, Universidad de Colima, Colima, Mexico, 6Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Universidad de Guadalajara, Guadalajara, Mexico, 7UMAE, Centro Médico Nacional de Occidente, IMSS; Doctorado en Farmacología, Universidad de Guadalajara, Jalisco, Mexico

    Background/Purpose: To identify the association between serum leptin and adiponectin levels and proteinuria secondary to lupus nephritis in women with systemic lupus erythematosus (SLE).  Methods:…
  • Abstract Number: 297 • 2013 ACR/ARHP Annual Meeting

    Plasma Nicotinamide Phosphoribosyltransferase Correlates With Markers Of Inflammation and May Predict Early Therapeutic Response To Low-Dose Methotrexate In Juvenile Idiopathic Arthritis

    Ryan S. Funk1, Leon van Haandel1, Marcia Chan2, Lanny J. Rosenwasser2, Andrew Lasky3, Maria F. Ibarra4, Mark F. Hoeltzel5, S.Q. Ye6, J.S. Leeder1 and Mara L Becker7, 1Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, MO, 2Pediatric Immunology Research, Children's Mercy Hospital, Kansas City, MO, 3Pediatrics Rheumatology, Children's Mercy Hospital, Kansas City, MO, 4Pediatric Rheumatolgy, Children's Mercy Hospital, Kansas City, MO, 5Rheumatology Section, Children's Mercy Hospital, Kansas City, MO, 6Medical Genetic Research, Children's Mercy Hospital, Kansas City, MO, 7Clinical Pharmacology and Rheumatology, Children's Mercy Hospital, Kansas City, MO

    Background/Purpose:   Despite a poor understanding of its biochemical role in the inflammatory process, nicotinamide phosphoribosyltransferase (NAMPT) has been implicated in a number of autoimmune…
  • Abstract Number: 44 • 2013 ACR/ARHP Annual Meeting

    Suppressor Of Cytokine Signaling 3 Negatively Modulates Leptin-Mediated Catabolic and Proinflammatory Effects In Cartilage – New Potential Mechanism To Target Obesity-Induced Osteoarthritis

    Anna Koskinen1, Katriina Vuolteenaho1, Riku Korhonen1, Teemu Moilanen1,2 and Eeva Moilanen1, 1The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, 2Coxa Hospital for Joint Replacement, Tampere, Finland

    Background/Purpose: Adipocytokine leptin has been suggested to link obesity and osteoarthritis (OA). Initially leptin was found to regulate energy metabolism through central nervous system. More…
  • Abstract Number: 2520 • 2012 ACR/ARHP Annual Meeting

    Suppressor of Cytokine Signaling 3 Is Reduced in Obese Patients with Osteoarthritis and Regulates Leptin Responses in Chondrocytes

    Anna Koskinen1, Katriina Vuolteenaho1, Riku Korhonen1, Teemu Moilanen2 and Eeva Moilanen1, 1The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, 2Coxa Hospital for Joint Replacement, Tampere, Finland

    Background/Purpose: Leptin is an adipokine whose concentrations in circulation are proportional to body fat stores and body mass index (BMI). Initially leptin was discovered to…
  • Abstract Number: 43 • 2012 ACR/ARHP Annual Meeting

    Serum Amyloid A Level in Knee Osteoarthritis: Systemic and/or Local Production and Pro-Inflammatory Properties On Human Chondrocytes and Fibroblast-Like Synoviocytes

    Dominique de Seny1, Gaël Cobraiville2, Sophie Neuville2, Edith Charlier3, Biserka Relic1, Florence Quesada Calvo3, Olivier Malaise3, Denis Malaise4, Laurence Lutteri5, Jean-Paul Chapelle5 and Michel G. Malaise1, 1Department of Rheumatology, GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, 2GIGA Research - University of Liège - CHU of Liège, Liège, Belgium, 3Department of Rheumatology, GIGA Research - University of Liège - CHU Liège, Liège, Belgium, 4University of Liège, Liège, Belgium, 5Medical Chemistry - CHU Liège, Liège, Belgium

    Background/Purpose: Knee osteoarthritis (OA) is a disease frequently seen in obese patients, but the relationship might be more linked to fat than to weight. A-SAA…
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