Abstracts tagged "Adipocytokines"

Abstract Number: 1803 • 2015 ACR/ARHP Annual Meeting
Serum Adipocyte Fatty Acid-Binding Protein Level Is Elevated in Patients with Systemic Lupus Erythematosus (SLE) but Not Associated with Biophysical Markers of Cardiovascular Disease
Anselm Mak^1,2, Herbert Schwarz³, Nien Yee Kow², Sen Hee Tay⁴ and Lieng Hsi Ling^2,5, ¹National University Health System, Singapore, Singapore, ²Medicine, National University of Singapore, Singapore, Singapore, ³Physiology, National Unversity of Singapore, Singapore, Singapore, ⁴National University of Singapore, Singapore, Singapore, ⁵National Unversity Heart Centre Singapore, National Unversity Health System, Singapore, Singapore
Background/Purpose: Adipocyte fatty acid-binding protein (aFABP) is an intracellular lipid-binding protein expressed in adipocytes and macrophages, particularly in inflammatory conditions. Recently, high circulating serum aFABP…
Abstract Number: 332 • 2015 ACR/ARHP Annual Meeting
Adipokine SERUM Levels in Patients with EARLY Knee Osteoarthritis with and without Metabolic Syndrome
Istar Guzman¹, Rolando Espinosa-Morales², Ignacio-Alfredo Valerio-Morales³, Austreberto Sanchez¹, Paulina P⁴ and Carlos Lozada¹, ¹Rheumatology, National Institute of Rehabilitation, Mexico, Mexico, ²Mexican Board of Rheumatology, Mexico City, Mexico, ³Rheumatology, National Institute of Rehablitation, Mexico, Mexico, ⁴Rheumatology, National institute of Rehabilitation, Mexico, Mexico
Background/Purpose: Osteoarthritis is a chronic, inflammatory, multifactorial disease. The metabolic syndrome (MS) has been linked to this disease; adipokines levels have been associated in the…
Abstract Number: 9 • 2015 ACR/ARHP Annual Meeting
Serum Visfatin Levels in Patients with Axial Spondyloarthitis and Early Rheumatoid Arthritis: Relation to Inflammation and Bone Changes
Hana Hulejova¹, Klára Prajzlerová², Olga Krystufkova², Krystýna Grobelná², Maria Filkova², Herman F Mann³, Karel Pavelka⁴, Jiri Vencovsky³ and Ladislav Senolt⁵, ¹Institute of Rheumatology and Department of Rheumatology, Prague, Czech Republic, ²Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, ³Institute of Rheumatology, Prague, Czech Republic, ⁴Charles University, Prague, Czech Republic, ⁵Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, Prague, Czech Republic
Background/Purpose: Visfatin may represent a novel biomarker of disease severity. Serum visfatin levels are elevated in patients with early rheumatoid arthritis (ERA) and axial spondyloarthritis…
Abstract Number: 532 • 2014 ACR/ARHP Annual Meeting
Adipose Tissue Is Prominent in Salivary Glands of Sjögren’s Syndrome Patients and Appears to Influence the Autoimmune Microenvironment in These Organs
Kathrine Skarstein^1,2, Lara Adnan Aqrawi³, Roland Jonsson^4,5 and Janicke Cecilie Liaaen Jensen⁶, ¹Gade Laboratorium for Pathology, Department of Clinical Medicine, University of Bergen, Bergen, Norway, ²Department of Pathology, Haukeland University Hospital, Bergen, Norway, ³Department of Clinical Science, University of Bergen, Bergen, Norway, ⁴Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, ⁵Department of Rheumatology, Haukeland University Hospital, Bergen, Norway, ⁶Department of Oral Surgery and Oral Medicine, University of Oslo, Oslo, Norway
Background/Purpose A positive salivary gland (SG) biopsy with a focus score of ≥1 is the only widely accepted pathological finding confirming the salivary gland component…
Abstract Number: 435 • 2014 ACR/ARHP Annual Meeting
Smoking Functions As a Negative Regulator of IGF-1 Levels and Adipokine Network in Patients with Rheumatoid Arthritis
Maria Bokarewa¹, Malin Erlandsson², Sofia Töyrä Silfverswärd³, Andreea Ioan-Fascinay⁴ and Roberto Doria Medina⁵, ¹Guldhedsgatan 10, University of Goteborg, Goteborg, Sweden, ²Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden, ³Rheumatology and Inflammation Research, University of Göteborg, Göteborg, Sweden, ⁴Rheumatology, Leiden University Medical Center, Leiden, Netherlands, ⁵University of Göteborg, Göteborg, Sweden
Background/Purpose Smoking is an important player in the pathogenesis of rheumatoid arthritis (RA) being tightly connected to the genetic (carriage of HLA-DRB1 shared epitope) and…
Abstract Number: 2933 • 2014 ACR/ARHP Annual Meeting
Metabolic Syndrome, Adipocytokines and Inflammation in Sjögren’s Syndrome
Kristopherson Lustosa Augusto¹, Eloisa Bonfá², Rosa M. R. Pereira¹, Cleonice Bueno³, Vilma S. T. Viana⁴ and Sandra G. Pasoto⁵, ¹Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ²Rheumatology Division, University of Sao Paulo, Sao Paulo, Brazil, ³Division of Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil, ⁴Rheumatology, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ⁵Rheumatology, Faculdade de Medicina da Universidade de São Paulo, Sao Paulo, Brazil
Background/Purpose Systemic inflammation has been linked to increased frequency of metabolic syndrome (MetS) in autoimmune diseases. However, there are no studies concerning the frequency of…
Abstract Number: 2474 • 2013 ACR/ARHP Annual Meeting
Fat Mass and Resistin: Predictive Factors For Anti-TNF Therapy Response In Ankylosing Spondylitis Patients
Carla G.S. Saad¹, Andressa Silva Abreu¹, Ana Cristina Medeiros Ribeiro¹, Julio C. B. Moraes², Luiz A. Perandini¹, Thalita Dassouki³, Rosa M. R. Pereira⁴, Eloisa Bonfa⁵ and Ana Lucia S. Pinto¹, ¹Reumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ²Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil, ³Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil, ⁴Reumatologia, Faculdade de Medicina, University of São Paulo, São Paulo, Brazil, ⁵Rheumatologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil
Background/Purpose: The adipose tissue immune properties and pharmacokinetic consequences can contribute to the pathogenesis of inflammatory conditions. The hole of fat tissue in active Ankylosing…
Abstract Number: 1397 • 2013 ACR/ARHP Annual Meeting
Changes In MMP In Fibroblast-Like Synoviocytes Following Adipogenesis
Satoshi Yamasaki, Kazuhiko Kumagai, Kouji Endo, Takaki Nojima and Eiji Sugiyama, Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan
Background/Purpose: Fibroblast-like synovial cells (FLS) play important roles in the disease progression of RA. FLS produce cytokines and chemokines that contribute to chronic inflammation…
Abstract Number: 727 • 2013 ACR/ARHP Annual Meeting
Adiponectin Promotes The Differentiation Of naïve T Cell To Th17 Cell and Aggravates Collagen-Induced Arthritis
Miaojia Zhang¹, Xiaoxuan Sun², Wenfeng Tan³, Xiaoke Feng⁴ and Ke Gan⁵, ¹Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA., Nanjing, China, ²Department of Rheumatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, CHINA, Nanjing, China, ³Rheumatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China, ⁴Rheumatology, the First Affiliated Hospital of Nanjing Medical University, China, Nanjing, China, ⁵Rheumatology Department, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
Background/Purpose: To investigate a role of Adiponectin (AD) on the differentiation of naïve T cell to Th17 cell and bone erosion in collagen-induced arthritis (CIA)…
Abstract Number: 599 • 2013 ACR/ARHP Annual Meeting
Association Between Serum Leptin and Adiponectin Levels With The Severity Of Proteinuria In Lupus Nephritis
Valeria Diaz-Rizo¹, Nicte Selene Fajardo-Robledo², Alan Joel Ruiz-Padilla², Dalia Sanchez-Mosco³, Tania Marlene Rodriguez-Hernandez⁴, Xochitl Trujillo⁵, Miguel Huerta⁵, Monica Vazquez del Mercado⁶, Laura Gonzalez-Lopez⁴ and Jorge Ivan Gamez-Nava⁷, ¹Doctorado en Ciencias Médicas, Centro Universitario de Investigación Biomédica, Universidad de Colima; UMAE, Hospital de Especialidades, Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jalisco, Mexico, ²Fisiología, Doctorado en Farmacología, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Jalisco, Mexico, ³Centro Universitario de Investigación Biomédica, Universidad de Colima; Hospital General Regional 110 IMSS, Guadalajara, Jalisco, Mexico, ⁴Departamento de Medicina Interna/Rheumatología, Hospital General Regional 110, Instituto Mexicano del Seguro Social (IMSS), Guadalajara, Jalisco, Mexico, ⁵Centro Universitario de Investigación Biomédica, Universidad de Colima, Colima, Mexico, ⁶Instituto de Investigación en Reumatología y del Sistema Músculo Esquelético, Universidad de Guadalajara, Guadalajara, Mexico, ⁷UMAE, Centro Médico Nacional de Occidente, IMSS; Doctorado en Farmacología, Universidad de Guadalajara, Jalisco, Mexico
Background/Purpose: To identify the association between serum leptin and adiponectin levels and proteinuria secondary to lupus nephritis in women with systemic lupus erythematosus (SLE). Methods:…
Abstract Number: 297 • 2013 ACR/ARHP Annual Meeting
Plasma Nicotinamide Phosphoribosyltransferase Correlates With Markers Of Inflammation and May Predict Early Therapeutic Response To Low-Dose Methotrexate In Juvenile Idiopathic Arthritis
Ryan S. Funk¹, Leon van Haandel¹, Marcia Chan², Lanny J. Rosenwasser², Andrew Lasky³, Maria F. Ibarra⁴, Mark F. Hoeltzel⁵, S.Q. Ye⁶, J.S. Leeder¹ and Mara L Becker⁷, ¹Clinical Pharmacology and Medical Toxicology, Children's Mercy Hospital, Kansas City, MO, ²Pediatric Immunology Research, Children's Mercy Hospital, Kansas City, MO, ³Pediatrics Rheumatology, Children's Mercy Hospital, Kansas City, MO, ⁴Pediatric Rheumatolgy, Children's Mercy Hospital, Kansas City, MO, ⁵Rheumatology Section, Children's Mercy Hospital, Kansas City, MO, ⁶Medical Genetic Research, Children's Mercy Hospital, Kansas City, MO, ⁷Clinical Pharmacology and Rheumatology, Children's Mercy Hospital, Kansas City, MO
Background/Purpose: Despite a poor understanding of its biochemical role in the inflammatory process, nicotinamide phosphoribosyltransferase (NAMPT) has been implicated in a number of autoimmune…
Abstract Number: 44 • 2013 ACR/ARHP Annual Meeting
Suppressor Of Cytokine Signaling 3 Negatively Modulates Leptin-Mediated Catabolic and Proinflammatory Effects In Cartilage – New Potential Mechanism To Target Obesity-Induced Osteoarthritis
Anna Koskinen¹, Katriina Vuolteenaho¹, Riku Korhonen¹, Teemu Moilanen^1,2 and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland
Background/Purpose: Adipocytokine leptin has been suggested to link obesity and osteoarthritis (OA). Initially leptin was found to regulate energy metabolism through central nervous system. More…
Abstract Number: 2097 • 2012 ACR/ARHP Annual Meeting
Adiponectin Is Associated with Pro-Inflammatory Cytokines in Autoantibody Positive First-Degree Relatives (FDRs) of Patients with Rheumatoid Arthritis
Jan M. Hughes-Austin¹, Kevin D. Deane², Lezlie A. Derber³, Gary O. Zerbe⁴, Dana M. Dabelea¹, Jeremy Sokolove⁵, William H. Robinson⁶, V. Michael Holers⁷ and Jill M. Norris⁸, ¹Epidemiology, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, ²Division of Rheumatology, University of Colorado School of Medicine, Aurora, CO, ³University of Colorado School of Medicine, Division of Rheumatology, Aurora, CO, ⁴Biostatistics and Informatics, Colorado School of Public Health / University of Colorado Anschutz Medical Campus, Aurora, CO, ⁵Medicine, VA Palo Alto Health Care System and Stanford University, Palo Alto, CA, ⁶Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA, ⁷Rheumatology Division, University of Colorado School of Medicine, Aurora, CO, ⁸Epidemiology, Colorado School of Public Health, Aurora, CO
Background/Purpose: While adiponectin is generally considered an anti-inflammatory adipokine, it has also been shown to participate in active RA in inflammatory, matrix-destructive and fibrotic processes…
Abstract Number: 2289 • 2012 ACR/ARHP Annual Meeting
Adiponectin Has Potent Anti-Fibrotic Effects Mediated Via AMP Kinase: Novel Target for Fibrosis Therap
Feng Fang¹, Lei Liu², Yang Yang², Jun Wei¹, Swati Bhattacharyya³, Ross Summer⁴, Boping Ye² and John Varga³, ¹Rheumatology Division, Northwestern University, Chicago, IL, ²School of Life Science and Technology, China Pharmaceutical University, Nanjing, China, ³Division of Rheumatology, Northwestern University, Chicago, IL, ⁴Pulmonary Center, Boston University, Boston, MA
Background/Purpose: Fibrosis in scleroderma is associated with transforming growth factor-β (TGF-β) signaling activation, collagen deposition and myofibroblast accumulation. Peroxisome proliferator activated receptor gamma (PPAR-γ) inhibits…
Abstract Number: 2520 • 2012 ACR/ARHP Annual Meeting
Suppressor of Cytokine Signaling 3 Is Reduced in Obese Patients with Osteoarthritis and Regulates Leptin Responses in Chondrocytes
Anna Koskinen¹, Katriina Vuolteenaho¹, Riku Korhonen¹, Teemu Moilanen² and Eeva Moilanen¹, ¹The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, ²Coxa Hospital for Joint Replacement, Tampere, Finland
Background/Purpose: Leptin is an adipokine whose concentrations in circulation are proportional to body fat stores and body mass index (BMI). Initially leptin was discovered to…