Abstracts tagged "Adhesion molecules"

Abstract Number: 1112 • 2016 ACR/ARHP Annual Meeting
Hypoxia Modulates Neutrophil Integrin Expression, Adhesion and Trans-Endothelial Migration
Akif A. Khawaja^1,2, Charis Pericleous^3,4, Vera M. Ripoll¹, Joanna C. Porter⁵ and Ian Giles³, ¹Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ²Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, ³Centre for Rheumatology, University College London, Centre for Rheumatology, University College London, London, United Kingdom, ⁴Imperial College Vascular Sciences, National Heart and Lung Institute, Imperial College Vascular Sciences, National Heart and Lung Institute, London, United Kingdom, ⁵Centre for Inflammation and Tissue Repair, Division of Medicine, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom
Background/Purpose: Dysregulation of neutrophil activation is important in the pathogenesis of various inflammatory and autoimmune rheumatic diseases (ARDs), including RA, SLE and APS. Neutrophils are…
Abstract Number: 2127 • 2016 ACR/ARHP Annual Meeting
Dicam Promotes Proliferation and Hypertrophic Differentiation of Chondrocyte through Indian Hedgehog Signaling of Primary Cilia
Seungwoo Han^1,2, Hye-Ri Park², Min-Su Han², Eun-Ju Lee², Ji-Ae Jang², Ji-Min Kim³, Gun-Woo Kim^2,4 and Younkwan Jung², ¹Internal Medicine, Daegu Fatima hospital, Daegu, Korea, The Republic of, ²Fatima Research Institute, Daegu, Korea, The Republic of, ³Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea, The Republic of, ⁴Rheumatology, Daegu Fatima hospital, Daegu, Korea, The Republic of
Background/Purpose: Chondrocytes in growth plate is known to respond to hydrostatic loading by increasing Indian hedgehog (Ihh) signaling, and that the primary cilium is required…
Abstract Number: 2148 • 2016 ACR/ARHP Annual Meeting
Recruitment of Circulating Monocytes By TNF/IL-6-Induced Expression of Vascular Cell Adhesion Molecule 1 (VCAM-1) Drives Valvular Inflammation in K/B/g7 Mice
Lee Meier¹, Jennifer L. Auger², Brianna J. Engelson³, Elise Breed⁴, Joshua Boyer⁵ and Bryce A. Binstadt², ¹Peadiatrics, University of Minnesota, Minneapols, MN, ²Center for Immunology and Department of Pediatrics, University of Minnesota, Minneapolis, MN, ³Pediatrics, University of Minnesota, Minneapolis, MN, ⁴Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, ⁵Medicine, University of Minnesota, Minneapolis, MN
Background/Purpose: Cardiovascular (CV) comorbidity is common in rheumatic diseases and includes accelerated atherosclerosis and inflammatory valvular heart disease (iVHD). KRN T cell receptor (TCR) transgenic…
Abstract Number: 2149 • 2016 ACR/ARHP Annual Meeting
Adipokines Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts Adhesion and Endothelial Cells
Rebecca Hasseli¹, Klaus W. Frommer², Markus Prof. Dr. Schönburg³, Stefan Prof. Dr. Rehart⁴, Ulf Müller-Ladner^5,6 and Elena Neumann², ¹Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, ³Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, ⁴Department of Orthopedics and Trauma Surgery, Markus Hospital, Frankfurt, Frankfurt, Germany, ⁵Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ⁶Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany
Background/Purpose: Synovial fibroblast plays a key role in rheumatoid arthritis (RA), which is a chronic polyarticular inflammatory disease. SF are able to migrate long distances…
Abstract Number: 209 • 2015 ACR/ARHP Annual Meeting
Different Autoimmune Rheumatic Diease IgG Have Differential Effects upon Neutrophil Binding, Activation and Neutrophil Extracellular Trap Formation
Akif A. Khawaja^1,2, Charis Pericleous³, Vera M. Ripoll², Joanna C. Porter⁴ and Ian Giles⁵, ¹Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, ²Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, ³Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, ⁴Centre for Inflammation and Tissue Repair, Division of Medicine, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, ⁵Rayne Intitiute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom
Background/Purpose: Dysregulation of neutrophil activation and function is important in the pathogenesis of various inflammatory and autoimmune rheumatic diseases (ARDs). Neutrophil dysfunction is well recognised…
Abstract Number: 4 • 2015 ACR/ARHP Annual Meeting
The Influence of Adipokines on the Interaction of Rheumatoid Arthritis Synovial Fibroblasts with Endothelial Cells
Rebecca Hasseli¹, Klaus W. Frommer², Thomas Dr. Umscheid³, Markus Prof. Dr. Schönburg⁴, Stefan Rehart⁵, Ulf Müller-Ladner² and Elena Neumann², ¹Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ²Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, ³William Harvey Klinik; Bad Nauheim, Germany, Bad Nauheim, Germany, ⁴Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, ⁵Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany
Background/Purpose: Rheumatoid Arthritis (RA) is a systemic chronic inflammatory disease. Adipose tissue, being an endocrine organ, plays an important role in inflammatory processes. Adipokines are…
Abstract Number: 1 • 2015 ACR/ARHP Annual Meeting
The Integrin Very Late Antigen-4 Plays a Key Role in the Recruitment of B Cells at the Inflammatory Foci
Estefanía Armas-González¹, Ana Díaz-Martín², María Jesús Domínguez-Luis³, María Teresa Arce-Franco² and Federico Díaz-González⁴, ¹Universidad de La Laguna, Pharmacology Department, Tenerife, Spain, ²Hospital Universitario de Canarias, Rheumatology Service, Tenerife, Spain, ³CIBICAN, Center of Biomedical Research of the Canary Islands, University of La Laguna, Tenerife, Spain, ⁴Investigation Unit, Sociedad Española de Reumatológía, Madrid, Spain
Background/Purpose: Experimental data suggest that B cells must migrate and accumulate into the synovial membrane to exert their pathogenic role in rheumatoid arthritis (RA). Leukocyte…
Abstract Number: 2993 • 2015 ACR/ARHP Annual Meeting
Serum CXCL4 Increase in Patients with Undifferentiated Connective Tissue Disease at Risk for Systemic Sclerosis Is Associated with Anti-Scl70 Antibodies and ICAM-1, a Marker of Endothelial Activation
Serena Vettori¹, Rosaria Irace², Veronica Giacco², Antonella Riccardi², Lucia Vicedomini², Luciana Pellecchia² and Gabriele Valentini², ¹Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, ²Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy
Background/Purpose: CXCL4 is a pleiotropic antiangiogenic and immunomodulatory chemokine, that has been shown to be increased in the sera of patients with systemic sclerosis (SSc)…
Abstract Number: 1964 • 2015 ACR/ARHP Annual Meeting
Biomarkers in Temporal Artery Biopsies and Sera of Patients with Giant Cell Arteritis
Katja Lakota¹, Tadeja Kuret², Polona Žigon¹, Ziga Rotar¹, Matija Tomsic¹, Saša Čučnik^1,2, Snezna Sodin Semrl^1,3 and Alojzija Hocevar¹, ¹Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia, ³Faculty of Mathematics, Natural Science and Information Technology, University of Primorska, Koper, Slovenia
Background/Purpose: Giant cell arteritis (GCA) is a large- and medium- vessel arteritis characterized by a range of histological patterns of vascular wall injury. The temporal…
Abstract Number: 1530 • 2015 ACR/ARHP Annual Meeting
Neutrophil Function and Survival Unaffected in Healthy Subjects Following Single Administration of Tocilizumab
Laurence Lok¹, Jatinder Juss¹, Neda Farahi¹, Chrystalla Loutsios¹, Chandra Solanki², Adrien Michael Peters³, Sophie Dimonaco⁴, Francis Donaldson⁴, Benjamin Porter-Brown⁴ and Edwin Chilvers¹, ¹Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, ²Department of Nuclear Medicine, Cambridge University Hospitals, Cambridge, United Kingdom, ³Division of Clinical and Laboratory Investigation, Brighton and Sussex Medical School, Brighton, United Kingdom, ⁴Roche Products Ltd., Welwyn Garden City, United Kingdom
Background/Purpose: Decreases in circulating neutrophil counts have been observed in adults with rheumatoid arthritis (RA) and children with systemic or polyarticular juvenile idiopathic arthritis treated…
Abstract Number: 2357 • 2014 ACR/ARHP Annual Meeting
Vascular Adhesion Molecule-1 Overexpression in Collagen-Induced Arthritis: Modeling Vascular Dysfunction in Rheumatoid Arthritis
Luca Semerano^1,2, Gaelle Clavel³, Delphine Lemeiter⁴, Marie-Christophe Boissier^4,5 and Anne Denys¹, ¹INSERM UMR U1125, University Paris 13, Sorbonne Paris Cité, Bobigny, France, ²Rheumatology, Avicenne Teaching Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP),, Bobigny, France, ³Fondation Ophtalmologique A. De Rothschild, Paris cedex 19, France, ⁴INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France, ⁵Rheumatology, AvicenneTeaching Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Bobigny, France
Vascular adhesion molecule-1 Overexpression in collagen-induced arthritis: modeling vascular dysfunctionS in rheumatoid arthritis Background/Purpose: Rheumatoid Arthritis (RA) patients are at risk of developing primary coronary…
Abstract Number: 2349 • 2014 ACR/ARHP Annual Meeting
Early Sympathectomy Inhibits Egress of Lymphocytes in Control and Arthritic Animals and Ameliorates Arthritic Disease
Susanne Klatt¹ and Rainer Straub², ¹Internal Medicine I, University Hospital Regensburg, Regensburg, Germany, ²Internal Medicine, University Hospital Regensburg, Regensburg, Germany

Background/Purpose: The sympathetic nervous system (SNS) plays an important role in course and development of autoimmune diseases like arthritis. In type II collagen- induced arthritis…
Abstract Number: 1975 • 2014 ACR/ARHP Annual Meeting
Profiling 14-3-3η in Human Primary Cell Based BioMAP^® Disease Models Reveals a Unique Pro-Inflammatory Phenotypic Signature Consistent with RA-Inflammation Biology
Alison O'Mahony¹, Ellen L. Berg¹, Walter P. Maksymowych², Yuan Gui³ and Anthony Marotta⁴, ¹BioSeek, South San Francisco, CA, ²Department of Medicine, University of Alberta, Edmonton, AB, Canada, ³Augurex Life Sciences Corp., North Vancouver, BC, Canada, ⁴1423 Dempsey Road, Augurex Life Sciences Corp., North Vancouver, BC, Canada
Background/Purpose 14-3-3 proteins represent a highly conserved seven-member family of ubiquitously expressed intracellular chaperonins that perform a broad range of signaling functions. The 14-3-3 eta…
Abstract Number: 1966 • 2014 ACR/ARHP Annual Meeting
CTLA4-Ig (abatacept) Modulate in Vitro the ICAM1 and VEGFR-2 Expression in Human Endothelial Cells
Maurizio Cutolo¹, Paola Montagna², Stefano Soldano², Paola Contini³, Barbara Villaggio⁴, Alberto Sulli¹, Sabrina Paolino¹, Carmen Pizzorni¹, Bruno Seriolo¹, Giuseppe Zampogna², Marco A. Cimmino¹ and Renata Brizzolara², ¹Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genoa, Italy, ²Research Laboratory and Academic Division of Clinical Rheumatology, Department of Internal Medicine, University of Genova, Genova, Italy, ³Division of Clinical Immunology, Department of Internal Medicine, University of Genova, Genova, Italy, ⁴Research Laboratory of Nephrology, Department of Internal Medicine, University of Genova, Genova, Italy
Background/Purpose CTLA4-Ig (abatacept) is employed as biological agent in rheumatoid arthtritis (RA) treatment and interacts with the costimulatory molecule CD86 expressed by different cells involved…
Abstract Number: 1028 • 2014 ACR/ARHP Annual Meeting
ADAM-10 Plays Monocyte Migration and Adhesion in Rheumatoid Arthritis Synovial Fibroblasts
Takeo Isozaki^1,2, Sho Ishii², Shinichiro Nishimi², Airi Maeoka², Mayu Saito², Nao Oguro², Shinya Seki², Yoko Miura², Yusuke Miwa², Koei Oh³, Yoichi Toyoshima³, Masanori Nakamura³, Katsunori Inagaki³ and Tsuyoshi Kasama², ¹Internal Medicine, Division of Rheumatology, University of Michigan Medical Center, Ann Arbor, MI, ²Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan, ³Department of Orthopedics, Showa University School of Med, Tokyo, Japan
Background/Purpose :A disintegrin and metalloprotease family proteins (ADAMs) have been reported to be involved in a number of inflammatory conditions. We previously reported that ADAM-10…