ACR Meeting Abstracts

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Abstracts tagged "Adhesion molecules"

  • Abstract Number: 2642 • 2017 ACR/ARHP Annual Meeting

    Lupus Serum Induces Glomerular Endothelial Cell Neutrophil Adhesion in Association with Soluble Mediators of Chemotaxis and Adhesion

    Dayvia Russell1, Margaret Markiewicz2 and Jim C. Oates3,4, 1Research Service, Ralph H. Johnson VA Medical Center, Charleston, SC, 2Division of Rheumatology and Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 3Division of Rheumatology & Immunology, Department of Medicine, Medical University of South Carolina, Charleston, SC, 4Medical Service, Ralph H. Johnson VA Medical Center, Charleston, SC

    Background/Purpose: Systemic lupus erythematosus (SLE) is associated with endothelial dysfunction, which can accelerated inflammation. Ingress of neutrophils into tissue requires chemotaxis and adhesion to endothelial…
  • Abstract Number: 8 • 2017 ACR/ARHP Annual Meeting

    Antiphospholipid Syndrome Leukocytes Demonstrate Increased Adhesive Potential:  a Search for Novel Therapeutic Targets

    Gautam Sule1, William J. Kelley1, Srilakshmi Yalavarthi1, Alison Banka1, Omolola Eniola-Adefeso1 and Jason S. Knight2, 1University of Michigan, Ann Arbor, MI, 2., University of Michigan, Ann Arbor, MI

    Background/Purpose: Adhesion of leukocytes to the endothelium is an initiating event in the thrombosis inherent to antiphospholipid syndrome (APS). Over the years, a number of…
  • Abstract Number: 960 • 2017 ACR/ARHP Annual Meeting

    ADAM-17 Is Expressed on Rheumatoid Arthritis Synovial Fibroblasts and Mediates Monocyte Migration and Adhesion

    Sho Ishii, Takeo Isozaki, Airi Nishimi, Shinichiro Nishimi, Takahiro Tokunaga, Hidekazu Furuya, Kuninobu Wakabayashi and Tsuyoshi Kasama, Div of Rheumatology, Showa University School of Med, Shinagawa-ku Tokyo, Japan

    Background/Purpose: A disintegrin and metalloproteinase 17 (ADAM-17), also known as tumor necrosis factor-α converting enzyme (TACE), have been reported to be involved in a number…
  • Abstract Number: 1921 • 2017 ACR/ARHP Annual Meeting

    Urine Angiostatin and VCAM-1 Surpass Conventional Metrics in Predicting Elevated Renal Pathology Activity Indices in Lupus Nephritis

    Samar Soliman1,2, Fatma Mohamed3, Faten Ismail3, Ramesh Saxena4 and Chandra Mohan2, 1Rheumatology and rehabilitation, University of Minya, Minya, Egypt, 2Biomedical Engineering, University of Houston, Houston, TX, 3Rheumatology and Rehabilitation, University of Minya, Minya, Egypt, 4Internal Medicine/Division of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX

    Background/Purpose: The goal of this study is to investigate how urinary angiostatin, VCAM-1 and established measures of renal function relate to specific histologic findings in…
  • Abstract Number: 1112 • 2016 ACR/ARHP Annual Meeting

    Hypoxia Modulates Neutrophil Integrin Expression, Adhesion and Trans-Endothelial Migration

    Akif A. Khawaja1,2, Charis Pericleous3,4, Vera M. Ripoll1, Joanna C. Porter5 and Ian Giles3, 1Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, 2Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, 3Centre for Rheumatology, University College London, Centre for Rheumatology, University College London, London, United Kingdom, 4Imperial College Vascular Sciences, National Heart and Lung Institute, Imperial College Vascular Sciences, National Heart and Lung Institute, London, United Kingdom, 5Centre for Inflammation and Tissue Repair, Division of Medicine, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom

    Background/Purpose: Dysregulation of neutrophil activation is important in the pathogenesis of various inflammatory and autoimmune rheumatic diseases (ARDs), including RA, SLE and APS. Neutrophils are…
  • Abstract Number: 2127 • 2016 ACR/ARHP Annual Meeting

    Dicam Promotes Proliferation and Hypertrophic Differentiation of Chondrocyte through Indian Hedgehog Signaling of Primary Cilia

    Seungwoo Han1,2, Hye-Ri Park2, Min-Su Han2, Eun-Ju Lee2, Ji-Ae Jang2, Ji-Min Kim3, Gun-Woo Kim2,4 and Younkwan Jung2, 1Internal Medicine, Daegu Fatima hospital, Daegu, Korea, The Republic of, 2Fatima Research Institute, Daegu, Korea, The Republic of, 3Division of Rheumatology, Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea, The Republic of, 4Rheumatology, Daegu Fatima hospital, Daegu, Korea, The Republic of

    Background/Purpose: Chondrocytes in growth plate is known to respond to hydrostatic loading by increasing Indian hedgehog (Ihh) signaling, and that the primary cilium is required…
  • Abstract Number: 2148 • 2016 ACR/ARHP Annual Meeting

    Recruitment of Circulating Monocytes By TNF/IL-6-Induced Expression of Vascular Cell Adhesion Molecule 1 (VCAM-1) Drives Valvular Inflammation in K/B/g7 Mice

    Lee Meier1, Jennifer L. Auger2, Brianna J. Engelson3, Elise Breed4, Joshua Boyer5 and Bryce A. Binstadt2, 1Peadiatrics, University of Minnesota, Minneapols, MN, 2Center for Immunology and Department of Pediatrics, University of Minnesota, Minneapolis, MN, 3Pediatrics, University of Minnesota, Minneapolis, MN, 4Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 5Medicine, University of Minnesota, Minneapolis, MN

    Background/Purpose: Cardiovascular (CV) comorbidity is common in rheumatic diseases and includes accelerated atherosclerosis and inflammatory valvular heart disease (iVHD). KRN T cell receptor (TCR) transgenic…
  • Abstract Number: 2149 • 2016 ACR/ARHP Annual Meeting

    Adipokines Alter the Interaction Between Rheumatoid Arthritis Synovial Fibroblasts Adhesion and Endothelial Cells

    Rebecca Hasseli1, Klaus W. Frommer2, Markus Prof. Dr. Schönburg3, Stefan Prof. Dr. Rehart4, Ulf Müller-Ladner5,6 and Elena Neumann2, 1Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 2Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad Nauheim, Germany, 3Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, 4Department of Orthopedics and Trauma Surgery, Markus Hospital, Frankfurt, Frankfurt, Germany, 5Department of Internal Medicine and Rheumatology, Justus-Liebig-University Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 6Justus-Liebig-University Giessen, Department of Internal Medicine and Rheumatology, Kerckhoff-Klinik, Bad Nauheim, Germany, Bad-Nauheim, Germany

    Background/Purpose: Synovial fibroblast plays a key role in rheumatoid arthritis (RA), which is a chronic polyarticular inflammatory disease. SF are able to migrate long distances…
  • Abstract Number: 209 • 2015 ACR/ARHP Annual Meeting

    Different Autoimmune Rheumatic Diease IgG Have Differential Effects upon Neutrophil Binding, Activation and Neutrophil Extracellular Trap Formation

    Akif A. Khawaja1,2, Charis Pericleous3, Vera M. Ripoll2, Joanna C. Porter4 and Ian Giles5, 1Centre for Inflammation and Tissue Repair, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, 2Centre for Rheumatology, Division of Medicine, Centre for Rheumatology, University College London, London, United Kingdom, 3Rayne Institute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom, 4Centre for Inflammation and Tissue Repair, Division of Medicine, Centre for Inflammation and Tissue Repair, University College London, London, United Kingdom, 5Rayne Intitiute, Centre for Rheumatology Research, UCL Division of Medicine, London, United Kingdom

    Background/Purpose: Dysregulation of neutrophil activation and function is important in the pathogenesis of various inflammatory and autoimmune rheumatic diseases (ARDs). Neutrophil dysfunction is well recognised…
  • Abstract Number: 4 • 2015 ACR/ARHP Annual Meeting

    The Influence of Adipokines on the Interaction of Rheumatoid Arthritis Synovial Fibroblasts with Endothelial Cells

    Rebecca Hasseli1, Klaus W. Frommer2, Thomas Dr. Umscheid3, Markus Prof. Dr. Schönburg4, Stefan Rehart5, Ulf Müller-Ladner2 and Elena Neumann2, 1Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 2Internal Medicine and Rheumatology, Justus-Liebig-University of Giessen, Kerckhoff-Klinik, Bad Nauheim, Germany, 3William Harvey Klinik; Bad Nauheim, Germany, Bad Nauheim, Germany, 4Department of Cardiac Surgery; Kerckhoff-Klinik, Bad Nauheim, Bad Nauheim, Germany, 5Orthopedics and Trauma Surgery, Markus-Hospital, Frankfurt, Germany

    Background/Purpose: Rheumatoid Arthritis (RA) is a systemic chronic inflammatory disease. Adipose tissue, being an endocrine organ, plays an important role in inflammatory processes. Adipokines are…
  • Abstract Number: 1 • 2015 ACR/ARHP Annual Meeting

    The Integrin Very Late Antigen-4 Plays a Key Role in the Recruitment of B Cells at the Inflammatory Foci

    Estefanía Armas-González1, Ana Díaz-Martín2, María Jesús Domínguez-Luis3, María Teresa Arce-Franco2 and Federico Díaz-González4, 1Universidad de La Laguna, Pharmacology Department, Tenerife, Spain, 2Hospital Universitario de Canarias, Rheumatology Service, Tenerife, Spain, 3CIBICAN, Center of Biomedical Research of the Canary Islands, University of La Laguna, Tenerife, Spain, 4Investigation Unit, Sociedad Española de Reumatológía, Madrid, Spain

    Background/Purpose: Experimental data suggest that B cells must migrate and accumulate into the synovial membrane to exert their pathogenic role in rheumatoid arthritis (RA). Leukocyte…
  • Abstract Number: 2993 • 2015 ACR/ARHP Annual Meeting

    Serum CXCL4 Increase in Patients with Undifferentiated Connective Tissue Disease at Risk for Systemic Sclerosis Is Associated with Anti-Scl70 Antibodies and ICAM-1, a Marker of Endothelial Activation

    Serena Vettori1, Rosaria Irace2, Veronica Giacco2, Antonella Riccardi2, Lucia Vicedomini2, Luciana Pellecchia2 and Gabriele Valentini2, 1Department of Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy, 2Internal and Experimental Medicine, Rheumatology Unit, Second University of Naples, Naples, Italy

    Background/Purpose: CXCL4 is a pleiotropic antiangiogenic and immunomodulatory chemokine, that has been shown to be increased in the sera of patients with systemic sclerosis (SSc)…
  • Abstract Number: 1964 • 2015 ACR/ARHP Annual Meeting

    Biomarkers in Temporal Artery Biopsies and Sera of Patients with Giant Cell Arteritis

    Katja Lakota1, Tadeja Kuret2, Polona Žigon1, Ziga Rotar1, Matija Tomsic1, Saša Čučnik1,2, Snezna Sodin Semrl1,3 and Alojzija Hocevar1, 1Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 2Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia, 3Faculty of Mathematics, Natural Science and Information Technology, University of Primorska, Koper, Slovenia

    Background/Purpose: Giant cell arteritis (GCA) is a large- and medium- vessel arteritis characterized by a range of histological patterns of vascular wall injury. The temporal…
  • Abstract Number: 1530 • 2015 ACR/ARHP Annual Meeting

    Neutrophil Function and Survival Unaffected in Healthy Subjects Following Single Administration of Tocilizumab

    Laurence Lok1, Jatinder Juss1, Neda Farahi1, Chrystalla Loutsios1, Chandra Solanki2, Adrien Michael Peters3, Sophie Dimonaco4, Francis Donaldson4, Benjamin Porter-Brown4 and Edwin Chilvers1, 1Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom, 2Department of Nuclear Medicine, Cambridge University Hospitals, Cambridge, United Kingdom, 3Division of Clinical and Laboratory Investigation, Brighton and Sussex Medical School, Brighton, United Kingdom, 4Roche Products Ltd., Welwyn Garden City, United Kingdom

    Background/Purpose: Decreases in circulating neutrophil counts have been observed in adults with rheumatoid arthritis (RA) and children with systemic or polyarticular juvenile idiopathic arthritis treated…
  • Abstract Number: 2357 • 2014 ACR/ARHP Annual Meeting

    Vascular Adhesion Molecule-1 Overexpression in Collagen-Induced Arthritis: Modeling Vascular Dysfunction in Rheumatoid Arthritis

    Luca Semerano1,2, Gaelle Clavel3, Delphine Lemeiter4, Marie-Christophe Boissier4,5 and Anne Denys1, 1INSERM UMR U1125, University Paris 13, Sorbonne Paris Cité, Bobigny, France, 2Rheumatology, Avicenne Teaching Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP),, Bobigny, France, 3Fondation Ophtalmologique A. De Rothschild, Paris cedex 19, France, 4INSERM UMR 1125, Li2P, University Paris 13, Sorbonne Paris Cité, Bobigny, France, 5Rheumatology, AvicenneTeaching Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Bobigny, France

     Vascular adhesion molecule-1 Overexpression in collagen-induced arthritis: modeling vascular dysfunctionS in rheumatoid arthritis    Background/Purpose: Rheumatoid Arthritis (RA) patients are at risk of developing primary coronary…
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