Session » Systemic Sclerosis, Fibrosing Syndromes and Raynaud’s – Pathogenesis, Animal Models and Genetics
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Abstract Number: 783
The Wnt Inhibitors DKK1 and SFRP1 Are Downregulated by Promoter Hypermethylation in Systemic Sclerosis
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Abstract Number: 784
Neutralization of Plasminogen Activator Inhibitor-1 Resolves Skin Fibrosis and Vascular Injury in a Murine Model of Human Scleroderma
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Abstract Number: 785
Resident Lung Fibroblast Gene Expression Signatures Predict Susceptibility or Resistance to Experimental Lung Fibrosis
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Abstract Number: 786
Crosstalk Between Integrins and TGFβ in the Pathogenesis and Treatment of Multiple Presentations of Scleroderma
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Abstract Number: 787
Aberrant Adipogenesis in the Pathogenesis of Scleroderma
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Abstract Number: 788
Tenofovir, a Potent Anti-Viral Agent, Is an Ecto-5’Nucleotidase (CD73) Inhibitor That Prevents Dermal Fibrosis in a Murine Model of Scleroderma
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Abstract Number: 1490
Dysregulation of Angiogenic Homeostasis in Systemic Sclerosis
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Abstract Number: 1491
Systemic Sclerosis – Effects of Agonistic Autoantibodies Directed Against the Angiotensin Receptor Type 1 and the Endothelin Receptor Type A On Effector Cells
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Abstract Number: 1492
IL-13 Receptors and Signaling in the Dermal Fibroblasts From Patients with Systemic Sclerosis
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Abstract Number: 1493
Transforming Growth Factor-β and Endothelin-1 Induce Endothelial-to-Mesenchymal Transition in Cultured Human Endothelial Cells
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Abstract Number: 1494
CD40 Signaling Results in Microvascular Endothelial Dysfunction: A Possible Clue to the Pathogenesis of Scleroderma Vasculopathy
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Abstract Number: 1495
Platelet Aggregability, Eicosanoid Biosynthesis and Oxidative Stress in Primary Raynaud’s Phenomenon and Systemic Sclerosis
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Abstract Number: 1496
Downregulated Expression of Metallothionein Genes in Response to the Gadolinium Contrast Agent Omniscan in Normal Human Differentiated Macrophages and Dermal Fibroblasts
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Abstract Number: 1497
Activation of Sirt1 Attenuates Bleomycin Induced Scleroderma Through Inhibiting Mammalian Target of Rapamycin Activation
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Abstract Number: 1498
Wisp-1 Neutralization Reduces Gvhd-Induced Skin Fibrosis by Altering TSLP-OX40L Axis-Dependent Th2 Responses
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Abstract Number: 1499
The Soluble Guanylate Cyclase Mediates Its Anti-Fibrotic Effects by Inhibiting TGF-β Signaling
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Abstract Number: 1500
Activation of Pregnane X Receptor Induces Regression of Experimental Dermal Fibrosis
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Abstract Number: 1501
Increased Periostin Levels in Patients with Systemic Sclerosis
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Abstract Number: 1502
Hedgehog Signaling in Murine Chronic Sclerodermatous Graft-Versus-Host Disease
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Abstract Number: 1503
Effect of Thiol Antioxidants On the Profibrotic Phenotype of Scleroderma Dermal Fibroblasts
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Abstract Number: 1505
Inactivation of Tankyrases Ameliorates Canonical Wnt Signaling and Prevents Experimental Fibrosis
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Abstract Number: 1506
Primary Human Scleroderma Dermal Endothelial Cells Exhibit Defective Angiogenesis
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Abstract Number: 1507
Propylthiouracil Reduces Fibrosis in Chronic Oxidant Stress Mouse Model of Scleroderma
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Abstract Number: 1508
Simvastatin Attenuates Pulmonary Fibrosis in a Murine Model of Systemic Sclerosis
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Abstract Number: 1509
Correlates of Skin Gene Expression Profile in Systemic Sclerosis
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Abstract Number: 1510
Critical Role of the Adhesion Receptor Dnax Accessory Molecule-1 (DNAM-1) in the Development of Inflammation-Driven Dermal Fibrosis in Mouse Model of Systemic Sclerosis
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Abstract Number: 1511
Low Circulating Endothelial Progenitor Cell Levels and High VEGF Serum Levels Are Associated with the Late Nailfold Capillaroscopic Pattern in Systemic Sclerosis
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Abstract Number: 1512
Bleomycin Delivery by Osmotic Pump: A Superior Model for Human ILD
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Abstract Number: 1513
TSLP Receptor Deficiency Reduces IL-13 Expression and Prevents Fibrosis in Experimental Scleroderma
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Abstract Number: 1514
Differences in the Activation Levels and Expression Patterns of the Molecular Targets of Tyrosine Kinase Inhibitors May Account for the Heterogeneous Treatment Responses
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Abstract Number: 1515
Pharmacological Blockade of Adenosine A2A Receptors (A2AR) Prevents Radiation-Induced Dermal Injury
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Abstract Number: 1516
TSLP Upregulation in Human SSc Skin and Induction of Overlapping Profibrotic Genes and Intracellular Signaling with IL-13 and TGFb
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Abstract Number: 1517
TLR9 Signaling in Fibroblasts Promotes Pro-Fibrotic Responses Via TGF-Beta
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Abstract Number: 1519
Heterogeneous Nuclear RNP-K Is a Novel Cold-Related Autoantigen in Patients with Raynaud’s Phenomenon
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Abstract Number: 1520
Role of 12/15-Lipoxygenase(LOX) in Patients with Systemic Sclerosis
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Abstract Number: 1521
A Possible Contribution of Decreased Cathepsin V Expression to the Development of Dermal Fibrosis, Proliferative Vasculopathy, and Altered Keratinocyte Phenotype in Systemic Sclerosis
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Abstract Number: 1522
Differential Response to Endoplasmic Reticulum Stress Between Alveolar Epithelial Cells and Lung Fibroblasts in Systemic Sclerosis
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Abstract Number: 2286
Dysregulated Discoidin Domain Receptor 2-Microrna 196a-Mediated Negative Feedback Against Excess Type I Collagen Expression in Scleroderma Dermal Fibroblasts
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Abstract Number: 2287
Altered Regulation of Metabolic Pathways in Systemic Sclerosis Evidenced by Metabolomics
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Abstract Number: 2288
The Role of TCR Vä1+ NKT Cells in Systemic Sclerosis Patients with Interstitial Pneumonitis
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Abstract Number: 2289
Adiponectin Has Potent Anti-Fibrotic Effects Mediated Via AMP Kinase: Novel Target for Fibrosis Therap
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Abstract Number: 2290
Type I Interferon Associated Gene IRF7 in the Pathogenesis of Fibrosis in Systemic Sclerosis (SSc)
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Abstract Number: 2291
Enhanced Release of S100A9 and Hepatocyte Growth Factor by the Epidermis in Systemic Sclerosis
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Abstract Number: 2292
Increased Synthesis of Leukotrienes by Peripheral Blood Mononuclear Cells Is Associated with More Severe Disease and Worse Prognosis in Patients with Systemic Sclerosis
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Abstract Number: 2293
Interleukin-17A Positive Cells Are Increased in Systemic Sclerosis Skin and Their Number Is Inversely Correlated to Skin Thickness
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Abstract Number: 2294
The Histone Deacetylase SIRT1 Is Anti-Fibrotic and Mediates Resveratrol Effects
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Abstract Number: 2295
Caveolin-1 Deficiency Induces Spontaneous Endothelial-to-Mesenchymal Transition (EndoMT) in Murine Pulmonary Endothelial Cells in Vitro
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Abstract Number: 2296
Platelet Release Products Mediate Endothelial Apoptosis: A Possible Role for Thrombospondin 1- CD36 Pathway in SSc-Endothelial Apoptosis
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Abstract Number: 2297
Decrease Activity of DNA Demethylase in SSc Fibroblast and Microvascular Endothelial Cells: A Possible Mechanism for Persistence of SSc Phenotype
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Abstract Number: 2299
Acroosteolysis Is Associated with Increased Propensity for Osteoclast Formation and Higher VEGF Levels in the Peripheral Blood of Systemic Sclerosis Patients
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Abstract Number: 2300
The Effects of Salvianolic Acid B in Fibrotic Models in Vivo and in Vitro
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Abstract Number: 2301
The Interferon Type I Signature Is Increased in Monocytes From Systemic Sclerosis Patients
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Abstract Number: 2302
Secreted Frizzled-Related Protein 4 Induces a Profibrotic Phenotype in Systemic Sclerosis Fibroblasts by Activating a Non-Canonical WNT Signaling Pathway
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Abstract Number: 2303
Confirmation of TNIP1 As a Susceptibility Locus for Systemic Sclerosis in a Large Multicentre Study
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Abstract Number: 2304
Differential Association of IRAK1 and MECP2 with Specific Systemic Sclerosis Phenotypes
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Abstract Number: 2306
Intratracheal Instillation of Omniscan in an Adenine-Induced Model of Chronic Renal Failure: A New Model of Nephrogenic Systemic Fibrosis
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Abstract Number: 2307
Role of Endosomal and Cell Membrane Toll-Like Receptors in Keratinocyte Activation by Systemic Sclerosis Autoantibodies