Date: Monday, November 9, 2015
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Background/Purpose: Although some individual dietary factors have been identified to be associated with the development of rheumatoid arthritis (RA), few studies have examined the effects of overall eating patterns on RA. We examined overall dietary patterns in relation to the risk of RA in a large prospective cohort, the Nurses’ Health Study II (NHSII).
Methods: We prospectively followed 93,859 women free of RA at baseline who provided dietary data from 1991 to 2011 in the NHS II. Dietary data were obtained from validated food frequency questionnaires in 1991 and every 4 years during follow-up. Two dietary patterns were identified using principal component analysis: the Prudent dietary pattern characterized by high intakes of fruit, vegetables, legumes, whole grains, poultry, and fish; the Western pattern characterized by high intakes of red meats, processed meats, refined grains, French fries, desserts and sweets, and high-fat dairy products. The cumulative average pattern scores over time were categorized into quartiles. Incident RA cases were validated by medical record review. Time-varying Cox proportional hazards models were used to calculate hazard ratios (HR) after adjusting for age, census-track income, smoking, body mass index (BMI), total calories, alcohol use and physical activity.
Results : During 1,509,033 person-years of follow-up, 626 incident cases of RA developed with the mean diagnosis age of 49. In the multivariable adjusted model, the Prudent pattern was associated with a reduced risk of RA, while the Western pattern was associated with an increased risk of RA (Table). The HRs (95% CI) across increasing quartiles of the Prudent pattern score were 1.00, 0.81(0.60,1.09),0.69(0.51,0.95), and 0.71(0.52,0.98) (p trend 0.04), and for the Western pattern, HRs ((95% CI) were 1.00, 1.41(1.01,1.98), 1.61(1.14,2.27), and 1.57(1.09,2.67) (p trend 0.03). After additional adjustment for BMI, the associations were attenuated.
Conclusion: In this female cohort study, dietary patterns were association with RA risk. A negative association was found between a Prudent diet rich in fruit, vegetables, and fish, and the risk of RA, whereas a positive association was found between a Western diet rich in refined grains, processed and red meats, desserts, and French fries, and the risk of RA. Further analysis of BMI as a potential confounder or mediator of these associations is warranted.
To cite this abstract in AMA style:Lu B, Hu Y, Sparks JA, Costenbader KH, Hu F, Karlson EW. Prospective Study of Dietary Patterns and Risk of Rheumatoid Arthritis in Women [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). https://acrabstracts.org/abstract/prospective-study-of-dietary-patterns-and-risk-of-rheumatoid-arthritis-in-women/. Accessed .
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