Session Type: ACR Poster Session C
Session Time: 9:00AM-11:00AM
Background/Purpose: Mixed connective tissue disease (MCTD) is an immune-mediated systemic disorder characterized by serum autoantibodies against U1-ribonucleoprotein and diverse multisystemic clinical manifestations. Approximately 50% of patients with MCTD develop a radiological pattern of interstitial lung disease (ILD). In this study, we explore the phenotypic and clinical features in patients with MCTD that are associated with development of ILD.
Methods: We performed a retrospective case control study utilizing data from patients evaluated at a single tertiary care center from 2007-2014. Twenty-eight patients who met validated criteria for diagnosis of MCTD were included in the study. Fourteen patients had high-resolution computed tomography or biopsy-proven ILD, and 14 had MCTD without evidence of ILD . We performed a multivariate logistic regression with multiple demographic, clinical, and serologic predictor variables, and ILD as the outcome variable.
Results: Two clinical variables had an association with development of ILD in patients with MCTD:
- Dysphagia with a R2 value of 0.33 (p value < 0.001)
- Raynaud’s phenomenon with R2 value of 0.28 (p value < 0.001)
We did not find a significant association between any other demographic, clinical, or serologic variables and development of ILD in patients with MCTD.
Conclusion: Dysphagia is one of the symptoms of esophageal involvement in patients with autoimmune connective tissue disorders. An association of dysphagia with the development of ILD in our study is in harmony with the existing literature, wherein esophageal dysmotility has been described in a cluster of patients with MCTD and ILD.
To cite this abstract in AMA style:Narula N, Narula T, Wang B, Abril A. Clinical Predictors for Development of Interstitial Lung Disease in Mixed Connective Tissue Disease [abstract]. Arthritis Rheumatol. 2016; 68 (suppl 10). http://acrabstracts.org/abstract/clinical-predictors-for-development-of-interstitial-lung-disease-in-mixed-connective-tissue-disease/. Accessed March 1, 2017.
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