Date: Monday, November 9, 2015
Session Title: Infection-related Rheumatic Disease: Poster Session
Session Type: ACR Poster Session B
Session Time: 9:00AM-11:00AM
Hepatitis C infection (HCV) is a leading cause of chronic liver disease. It is associated with a plethora of autoimmune manifestations including clinical, serological and pathological abnormalities affecting different organs. Immune dysregulation in HCV is further indicated by the high prevalence of non-organ specific antibodies. We investigated the autoimmune manifestations in HCV including clinical, laboratory, imaging and pathological data with emphasis on serologies.
We conducted a retrospective chart review in Rheumatology clinic on patients with HCV (confirmed by viral RNA) as a cofactor. We collected the demographic, clinical, laboratory, imaging and pathological data on these patients. We investigated the extent of autoimmune manifestations and its correlation to the degree of hepatic damage.
We obtained data on 29 patients of whom a limited number had available serological data. 41.3% had a coexisting autoimmune disease with Rheumatoid arthritis (RA) as the most common (33.3%). Arthralgia and Raynaud’s were seen in 79.3% and 10.3% respectively. A positive ANA was demonstrated in 61.5% and ENA was demonstrated in 22.2%. Smith and RNP antibodies were detected in 25% and 50% respectively in the absence of clinical Lupus. ANCA was detected in 20% and cryoglobulins in 28% in the absence of clinical vasculitis. Rheumatoid Factor (RF) and Anti-CCP were seen in 45% and 22.2% respectively. 22.2% of patients with RF and 5.5% of patients with Anti-CCP did not have clinical RA. Antiphospholipid antibodies were seen in 40% in the absence of thromboembolic disease. Serologies were confounded by illicit drugs in 20%. The severity of autoimmune manifestations and serological abnormalities did not track the severity of hepatic damage.
Significant autoimmune manifestations including serological abnormalities and cryoglobulinemia can be seen in hepatitis C in the absence of a clinical disease. Autoimmune manifestations do not parallel the degree of hepatic damage in hepatitis C.
To cite this abstract in AMA style:Ali A, Khan R, Lilley K, Naylor P, Namas R, Venkatram M. Autoimmune Manifestations in Hepatitis C: A Single-Centered Experience [abstract]. Arthritis Rheumatol. 2015; 67 (suppl 10). http://acrabstracts.org/abstract/autoimmune-manifestations-in-hepatitis-c-a-single-centered-experience/. Accessed January 22, 2018.
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